La restricción dietaria de calcio produce alteraciones metabólicas
DOI:
https://doi.org/10.31053/1853.0605.v66.n2.23532Palabras clave:
dietas deficientes en calcio, metabolismo hormonal, cáncer, huesoResumen
El calcio (Ca2+) es fundamental para la formación de los huesos y dientes y es esencial para alcanzar el pico de masa ósea. Además, el Ca2+ es un importante regulador de diferentes procesos fisiológicos. Los requerimientos diarios de Ca2+ dependen de la edad, sexo y diferentes estados fisiológicos, siendo mayores en los adolescentes, en el embarazo y en la lactancia. Con dietas deficientes en Ca2+, la secreción de distintas hormonas calciotrópicas se modifica y el transporte duodenal y la reabsorción renal del catión se incrementan, por lo que el metabolismo óseo también está fuertemente alterado. Hay también evidencias de que existe asociación entre la baja ingesta de Ca2+ y la hipertensión arterial e incremento en el riesgo de contraer cáncer.
Descargas
Referencias
Ma, J, Johns, RA, Stafford, RS: Americans are not meeting current calcium recommendations. Am J Clin Nutr; 2007, 85: 1361-1366.
Petre-Lazar, B, Livera, G, Moreno, SG, Trautmann, E, Duquenne, C, Hanoux, V, Habert, R, Coffigny, H: The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol; 2007, 210: 87-98.
Kranz, S, Lin, PJ, Wagstaff, DA: Children’s dairy intake in the United States: too little, too fat?. J Pedriatr; 2007, 151: 642-646.
Bhatia, V: Dietary calcium intake – a critical reappraisal. Indian J Med Res; 2008, 127: 269-273.
Pérez, A, Ulla, M, García, B, Lavezzo, M, Elías, E, Binci, M, Rivoira, M, Centeno, V, Alisio, A, Tolosa de Talamoni, N: Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women. J Bone Miner Metab; 2008, 26: 358-365.
Centeno, VA, Díaz de Barboza, GE, Marchionatti, AM, Alisio, AE, Dallorso, ME, Nasif, R, Tolosa de Talamoni, NG: Dietary calcium deficiency increases Ca2+ uptake and Ca2+ extrusion mechanisms in chick enterocytes. Comp Biochem Physiol A; 2004, 139: 133-141.
Centeno, V, Díaz Barboza, G, Marchionatti, A, Rodriguez, V, and Tolosa de Talamoni N: Molecular mechanisms triggered by low-calcium diets. Nutr Res Rev; 2009, 22: 163-74.
Tolosa de Talamoni, N, Centeno V: Low calcium diets in humans and in experimental animals: classics models to understand calcium homeostasis and vitamin D endocrine systems. Endocrinologia; 1999, 46: 241-244.
Swaminathan, R, Sommerville, BA, Care, AD: The effect of dietary calcium on the activity of 25-hydroxycholecalciferol- 1-hydroxylase and Ca absorption in vitamin D-replete chicks. Br J Nutr; 1997, 38: 47-54.
Schedl, HP, Conway, T, Horst, RL, Miller, DL, Brown, CK: Effects of dietary calcium and phosphorus on vitamin D metabolism and calcium absorption in hamster. Proc Soc Exp Biol Med; 1996, 211: 281-286.
Stumpf, WE: Vitamin D and the digestive system. Eur J Drug Metab Pharmacokinet.; 2008, 33: 85-100.
Fleet, JC, Gliniak, C, Zhang, Z, Xue, Y, Smith, KB, McCreedy, R, Adedokun, SA: Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice. J Nutr; 2008, 138: 1114-1120.
Christakos, S, Dhawan, P, Liu, Y, Peng, X, Porta, A: New insights into the mechanisms of vitamin D action. J Cell Biochem; 2003, 88: 695-705.
Pasch, A, Frey, FJ, Eisenberger, U, Mohaupt, MG, Bonny, O: PTH and 1.25 vitamin D response to a lowcalcium diet is associated with bone mineral density in renal stone formers. Nephrol Dial Transplant; 2008, 23: 2563-2570.
Díaz, R, El-Hajj, G, Brown, E: Parathyroid hormone and poly hormones: production and export. In Handbook of physiology: endocrine regulation of water and electrolyte balance. 2000: pp. 607-662 [Y Fray, editor]. New York, Oxford University Press.
Miao, D, Li, J, Xue, Y, Su, H, Karaplis, AC, Goltzman, D: Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice. Endocrinology; 2004, 145: 3554-3562.
Zhang, Y, Lai, WP, Wu, CF, Favus, MJ, Leung, PC, Wong, MS: Ovariectomy worsens secondary hyperparathyroidism in mature rats during low-Ca diet. Am J Physiol Endocrinol Metab; 2007, 292: E723-E731.
Canaff, L, Zhou, X, Hendy, GN: The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J Biol Chem; 2008, 283: 13586 - 13600.
Ferrari, S, Bonjour, JP, Rizzoli, R: The vitamin D receptor gene and calcium metabolism. Trends Endocrinol Metab; 1998, 9: 259-265.
Tolosa de Talamoni, N, Mykkanen, H, Wasserman, R: Enhancement of sulfhydryl groups availability in the intestinal brush border membrane by deficiencies of dietary calcium and phosphorus in chicks. J Nutr; 1990, 20: 1198-1204.
Mykkanen, HM, Wasserman, RH: Uptake of 75Seselenite by brush border membrane vesicles from chick duodenum stimulated by vitamin D. J Nutr; 1989, 119: 242-247.
Benn, BS, Ajibade, D, Porta, A, Dhawan, P, Hediger, M, Peng, JB, Jiang, Y, Oh, GT, Jeung, EB, Lieben, L, Bouillon, R, Carmeliet, G, Christakos, S: Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology; 2008, 149: 3196-3205.
Murayama, A, Takeyama, K, Kitanaka, S, Kodera, Y, Kawaguchi, Y, Hosoya, T, Kato, S: Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals. Endocrinology; 1999, 140: 2224-2231.
Omdahl, JL, Morris, HA, May, BK: Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation. Annu Rev Nutr; 2002, 22: 139-166.
Pasch, A, Frey, FJ, Eisenberger, U, Mohaupt, MG, Bonny, O: PTH and 1.25 vitamin D response to a lowcalcium diet is associated with bone mineral density in renal stone formers. Nephrol Dial Transplant; 2008, 23: 2563-2570.
Kalkwarf, HJ, Khoury, JC, Lanphear, BP: Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women. Am J Clin 27. Kasukawa, Y, Baylink, DJ, Wergedal, JE, Amaar, Y, Srivastava, AK, Guo, R, Mohan, S: Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice. Endocrinology; 2003, 144: 4682-4689.
Bezerra, FF, Mendonça, LM, Lobato, EC, O'Brien, KO, Donangelo, CM: Bone mass is recovered from lactation to postweaning in adolescent mothers with low calcium intakes. Am J Clin Nutr; 2004, 80: 1322-1326.
Avenell, A, Gillespie, WJ, Gillespie, LD, O'Connell, D: Vitamin D and vitamin D analogues for preventing fractures associated with involutional and postmenopausal osteoporosis. Cochrane Database Syst Rev; 2009, 2.
Bucher, HC, Guyatt, GH, Cook, RJ, Hatala, R, Cook, DJ, Lang, JD, Hunt, D: Effect of calcium suplementation on pregnancy-induced hypertension and preeclampsia: a meta- analysis of randomized controlled trails. JAMA; 1996, 275: 1113-1117.
Wang, L, Manson, JE, Buring, JE Lee, IM, Sesso, HD: Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension; 2008, 51: 1073-1079.
Murtaugh, MA, Sweeney, C, Ma, KN, Potter, JD, Caan, BJ, Wolff, RK, Slattery, ML: Vitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer. Nutr Cancer; 2006, 55: 35 – 43.
Levi, F, Pasche, C, Lucchini, F et al. Selected micronutrients and colorectal cancer. a case-control study from the canton of Vaud, Switzerland. Eur J Cancer; 2000, 36: 2115-2129.
Farrow, DC, Davis, S: Diet and the risk of pancreatic cancer in men. Am J Epidemiol; 1990, 132: 423- 431.
Torniainen, S, Hedelin, M, Autio, V, Rasinperä, H, Bälter, KA, Klint, A, Bellocco, R, Wiklund, F, Stattin, P, Ikonen, T, Tammela, TL, Schleutker, J, Grönberg, H, Järvelä, I.: Lactase persistence, dietary intake of milk, and the risk for prostate cancer in Sweden and Finland. Cancer Epidemiol Biomarkers Prev; 2007, 16: 956-961.
Bonjour, JP, Chevalley, T, Fardellone, P: Calcium intake and vitamin D metabolism and action, in healthy conditions and in prostate cancer. Br J Nutr; 2007, 97: 611-616.
Skinner, HG, Michaud, DS, Giovannucci, E, Willett, WC, Colditz, GA, Fuchs, CS: Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev; 2006, 15: 1688-1695.
Kuokkanen, M, Butzow, R, Rasinperä, H, Medrek, K, Nilbert, M, Malander, S, Lubinski, J, Järvelä, I: Lactase persistence and ovarian carcinoma risk in Finland, Poland and Sweden. Int J Cancer; 2005, 117: 90-94.
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2009 Universidad Nacional de Córdoba
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
Se permite la generación de obras derivadas siempre que no se haga con fines comerciales. Tampoco se puede utilizar la obra original con fines comerciales.