Utilización de aspirina 100 mg/día para prevenir Preeclampsia, en embarazos de alto riego, en una cohorte de Argentina

Walter Gaston Espeche; Julian Minetto; Martin Rogelio Salazar

doi:10.31053/1853.0605.v79.n1.32783

Authors

Walter Gaston Espeche
Julian Minetto UNLP
Martin Rogelio Salazar https://orcid.org/0000-0002-7103-5505

DOI:

https://doi.org/10.31053/1853.0605.v79.n1.32783

Keywords:

preeclampsia, eclampsia, hypertension, pregnancy, aspirin

Abstract

Objectives

The objective of the present study was to analyse the use of 100 g aspirin dose as prevention method for preeclampsia in high risk pregnant patients.

Methods

A retrospective cohort study was performed in high risk pregnant patients with a blood pressure protocol, and the use of 100 mg of aspirin vs. its non-use was evaluated in the incidence of PREEC. Estimations between the two groups were performed with and without variable adjustment by means of binary logistic regression models.

Results

633 high risk pregnant patients were evaluated. The average age was 30±7 years old, and 25±8 weeks of pregnancy. 281 women (44.3 %) within this group received aspirin.

The total prevalence of PREEC in our sample was 151 pregnant women (23.8 %).
Pregnant patients under the aspirin treatment developed less PREEC events (19.2% vs 27.5%, p=0.019); with OR not adjusted 0.62 (IC95% 0.43-0.91 p= 0.017). The risk was similar when it was adjusted by age, preeclampsia history, diabetes mellitus and chronic high blood pressure. (OR adjusted 0.63 IC95% 0.43-0.92 p= 0.017).

Conclusions

The use of 100 mg of aspirin a day before the 20th week of pregnancy in high risk pregnant patients decreased the risk of developing PREEC, regardless the age and risk factors.

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Author Biographies

Walter Gaston Espeche
- Especialista en Clínica Médica. Título de especialista otorgado por del Colegio de Médicos de la Provincia de Buenos Aires. Distrito I.
- Master en Enfermedad Cardiovascular. Organizado por la Cátedra de Medicina Interna de la Universidad de Barcelona y la Sociedad Española de Medicina Interna, en colaboración con la Sociedad Latino-Americana de Hipertensión (LASH) y la Sociedad Argentina de Hipertensión Arterial (SAHA).
- Medico de Planta del Hospital San Martín de La Plata con cargo de 36 horas en Clínica Médica. Cargo ganado por concurso. Desde 01-09-2009 hasta la actualidad.
- Jefe de Sala de Clinica Medica. Servicio de Clínica Médica. Hospital San Martin de La Plata. Desde 01-09-2012 hasta la actualidad.
- Coordinador de la Unidad de enfermedades cardiometabolicas del Hospital San Martin de La Plata desde Septiembre 2013 a la actualidad.
- Docente diplomado rentado simple desde Agosto de 2014 en Cátedra “D” de Medicina Interna hasta 2020. Cargo ganado por concurso.
- Profesor Adjunto desde 2020 en Cátedra “D” de Medicina Interna en la Facultad de ciencias Medicas en la Universidad Nacional de La Plata hasta la actualidad.
- Editor ejecutivo de la Revista de Docencia e Investigación del Hospital San Martin de La Plata. Servicio de Docencia e investigación. La Plata. Argentina Desde 2017 a la actualidad.
- Editor de Revista de la Sociedad Argentina de Hipertensión Arterial Desde 2017.
- Vice-Presidente 2do de la Sociedad Argentina de Hipertensión Arterial.
Julian Minetto, UNLP

- Médico de Planta interino del Servicio de Clinica Médica del Hospital Interzonal de Agudos San Martin de La Plata.

- Médico de la Unidad de enfermedades cardiometabolicas del Hospital Interzonal de Agudos San Martin de La Plata.

- Ayudante diplomado Catedra de Medicina interna D y C en la facultad de ciencias médicas, Universidad Nacional de La Plata.

- Ayudante diplomado en Cátedra Farmacología Aplicada en la facultad de ciencias médicas, Universidad Nacional de La Plata.

- Miembro adherente Sociedad Argentina de Hipertension Arterial.
Martin Rogelio Salazar
- Especialista en Clínica Médica. Título de especialista otorgado por del Colegio de Médicos de la Provincia de Buenos Aires. Distrito I.
- Ex-Jefe de Servicio de Clínica Médica del Hospital Interzonal de Agudos San Martín, La Plata, Argentina.
- Ex-Coordinador de la Unidad de enfermedades cardiometabolicas en el Hospital Interzonal de Agudos San Martín de La Plata.
- Jefe de Servicio de Docencia e Investigación del Hospital Interzonal de Agudos San Martín, La Plata, Argentina
- Profesor Titular de Medicina Interna D de la Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina
- Miembro de la Comisión directiva SAHA: Secretario de la Sociedad Argentina de Hipertension.

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