Palavras-chave
stress
biomarcadores
colesterol HDL
carga alostática
Como Citar
Resumo
O objetivo deste estudo foi determinar a relação entre stress e variáveis sociodemográficas e biomarcadores de carga alostática em doentes com doença arterial coronária aguda. Estudo transversal, em pacientes com doença arterial coronária confirmada por angiografia coronária. O stress foi medido através da escala de stress percebido e as variáveis sociodemográficas e clínicas foram retiradas dos registos médicos. As covariáveis foram analisadas através de estatística descritiva. Foram formados dois grupos de acordo com a presença ou ausência de stress no momento da hospitalização; foi avaliada a diferença entre os grupos. A correlação foi explorada por regressão linear. Foram recrutados 138 doentes, 50% dos quais tinham 65 anos ou mais, 65,9% eram do sexo masculino, o enfarte agudo do miocárdio foi o principal diagnóstico documentado e o fator de risco mais frequente foi a hipertensão arterial. 22,8% dos doentes foram submetidos a stress. O HDL foi mais elevado nos doentes com stress (Me 45,57) em comparação com os doentes sem stress (Me 39,12), sendo um fator diferenciador (p= 0,024). A análise multivariada encontrou uma relação positiva (r: 0,3; p: 0,003) do HDL com o stress e uma relação inversa (r: -0,95; p: 0,02) do IMC com o HDL nos homens. Os resultados sugerem uma relação direta e significativa entre níveis elevados de HDL e stress, e o HDL pode atuar como um fator pró-inflamatório na fase aguda da doença coronária aguda.
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