PREVALÊNCIA DA COINFECÇÃO HIV-1/HTLV-1 E RISCO COMPORTAMENTAL ENTRE PESSOAS VIVENDO COM HIV EM BELO HORIZONTE, BRASIL

Autores

  • Poliane Cristina Vertêlo
  • Alexandre Braga Miranda
  • Ludimila Labanca
  • Ana Lúcia Borges-Starling
  • Cláudio Daniel Cerdeira UNIFAL-MG
  • Carlos Felipe Nogueira
  • Denise Utsch Gonçalves

DOI:

https://doi.org/10.31052/1853.1180.v28.n2.38078

Palavras-chave:

HTLV-1, HIV-1, coinfecção, comportamento

Resumo

Objetivos: Neste estudo analisou-se à prevalência da coinfecção HIV-1 e HTLV-1 e os comportamentos de risco para infecções sexualmente transmissíveis (ISTs) e a qualidade de vida entre pessoas vivendo com HIV-1 (PV-HIV-1). Métodos: 985 PV-HIV-1 em Belo Horizonte (Brasil) foram submetidas a triagem sorológica para HTLV-1. Quinze casos confirmados (por Western blot) para a coinfecção HIV-1/HTLV-1 (grupo HIV-1/HTLV-1) foram comparados com 30 pacientes HIV-1 (grupo HIV-1) e 30 HTLV-1 (grupo HTLV- 1), grupos pareados por sexo biológico e faixa etária, analisando-se à situação sociodemográfica/qualidade de vida e os fatores de risco/comportamentais para ISTs. Resultados: A prevalência da coinfecção HIV-1/HTLV-1 foi 1,5%. A média de idade dos três grupos foi 57 (± 11) anos, sendo 9 e 18 (60%) mulheres nos grupos HIV-1/HTLV-1 e HIV-1 ou HTLV-1, respectivamente. A orientação heterossexual predominou nos três grupos. Os grupos HIV-1/HTLV-1 e HIV-1 não apresentaram na maioria dos casos parceiro fixo (p = 0,013), eram solteiros (p = 0,001) e referiram ao uso de preservativo (p = 0,025). A maioria no grupo HTLV-1 apresentava parceiro fixo, eram casados e não usava preservativo (p = 0,025). Entre outras ISTs, a sífilis foi comum nos grupos HIV-1/HTLV-1 (34%) e HIV-1 (17%), e gonorreia (13%) no grupo HTLV-1. O uso de drogas intravenosas (UDI) no grupo HIV-1 foi associado à coinfecção (p = 0,038), e a qualidade de vida diferiu entre os grupos. Conclusões: Os grupos HIV-1 e HIV-1/HTLV-1 apresentaram comportamentos de risco diferentes do grupo HTLV-1. As medidas de prevenção da disseminação do HIV-1 e HTLV-1 também devem destacar o UDI em PV-HIV-1 e o uso de preservativo em pessoas vivendo com HTLV-1.

Downloads

Os dados de download ainda não estão disponíveis.

Referências

Carneiro-Proietti ABF, Ribas JGR, Catalan-Soares BC, Martins ML, Brito-Melo GEA, Martins-Filho OA, et al. Infection and disease caused by the human T cell lymphotropic viruses type I and II in Brazil. Revista da Sociedade Brasileira de Medicina Tropical. 2002; 35(5): 499-508.

https://doi.org/10.1590/S0037-86822002000500013

Gonçalves DU, Proietti FA, Ribas JGR, Araújo MG, Pinheiro SR, Guedes AC, et al. Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1 associated diseases. Reviews Clinical Microbiology. 2010; 23(3): 577–589. https://doi.org/10.1128/CMR.00063-09

Ishak R, Ishak MOG, Vallinoto ACR. The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil. Retrovirology. 2020; 17: 4.

https://doi.org/10.1186/s12977-020-0512-z

Pereira FM, Almeida MCC, Santos FLN, Carreiro RP, Regis-Silva CG, Galvão-Castro B, et al. Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil. Front Microbiol. 2019; 10: 1002.

https://doi.org/10.3389/fmicb.2019.01002

Catalan-Soares B, Carneiro-Proietti ABF, Proietti FA. Heterogeneous geographic distribution of human T cell lymphotropic viruses I and II (HTLV-I/II): serological screening prevalence rates in blood donors from large urban areas in Brazil. Caderno de Saúde Pública. 2005; 21(3): 926-931.

https://doi.org/10.1590/S0102-311X2005000300027

Brito AM, Castilho EA, Szwarcwald CL. AIDS and HIV infection in Brazil: a multifaceted epidemic. Revista da Sociedade Brasileira de Medicina Tropical. 2000; 34(2): 207-217.

https://doi.org/10.1590/S0037-86822001000200010

Nogueira CF, Cerdeira CD, Prado AC, Dias RPCS, Silva RBV, Vertêlo PC, et al. Perfil de pessoas vivendo com HIV em um centro de referência em doenças infectocontagiosas de Belo Horizonte (MG, Brasil). Rev Med Saúde Brasília. 2020; 9(1): 76-89. https://bit.ly/3o0RKSf

Bastos SH, Taminato M, Fernades H, de Figueiredo TMRM, Nichiata LYI, Hino P. Sociodemographic and health profile of TB/HIV co-infection in Brazil: a systematic review. Rev Bras Enferm. 2019; 72(5): 1389-96.

https://doi.org/10.1590/0034-7167-2018-0285

Brites C, Alencar R, Gusmão R, Pedroso C, Netto EM, Pedral-Sampaio D, et al. Co-infection with HTLV-1 is associated with a shorter survival time for HIV-1 infected patients in Bahia, Brazil. AIDS (London, England). 2001; 15(15): 2053-2055.

https://doi.org/10.1097/00002030-200110190-00023

Ribeiro ML, Gonçalves JP, Morais VMS, Moura LCRV, Coêlho MRCD. HTLV 1/2 Prevalence and risk factors in individuals with HIV/AIDS in Pernambuco, Brazil. Revista da Sociedade Brasileira de Medicina Tropical. 2019; 52: e20180244.

https://doi.org/10.1590/0037-8682-0244-2018

11. Galvão-Castro B, Loures L, Rodrigues LG, Sereno A, Ferreira Júnior OC, Franco LG, et al. Distribution of human T-lymphotropic virus type I among blood donors: a nationwide Brazilian study. Transfusion. 1997; 37(2): 242-3.

https://doi.org/10.1046/j.1537-2995.1997.37297203532.x

Paiva AM, Assone T, Haziot MEJ, Smid J, Fonseca LAM, do Carmo Luiz O, et al. Risk factors associated with HTLV-1 vertical transmission in Brazil: longer breastfeeding, higher maternal proviral load and previous HTLV-1-infected offspring. Scientific Reports. 2018; 8: 7742.

https://doi.org/10.1038/s41598-018-25939-y

Royce RA, Seña A, Cates W Jr, Cohen MS. Sexual transmission of HIV. The New England Journal of Medicine. 1997; 336: 1072-1078.

https://doi.org/10.1056/nejm199704103361507

Allain JP, Stramer SL, Carneiro-Proietti ABF, Martins ML, Lopes da Silva SN, Ribeiro M, et al. Transfusion-transmitted infectious diseases. Biologicals. 2009; 37(2): 71-77. https://bit.ly/3u35bFc

Canini SRMS, Reis RB, Pereira LA, Gir E, Pelá NTR. HIV/AIDS patients quality of life: a literature review. Revista Latino-Americana Enfermagem. 2004; 12(6): 940-5. https://doi.org/10.1590/s0104-11692004000600014

Souza ARM, Thuler LCS, Lopez RRA, Puccioni-Sohler M. Prevalence of major depression and symptoms of depression in patients with HTLV-1 infections. J Bras Doenças Sexualmente Transmissíveis. 2009; 21(4): 163-165.

www.dst.uff.br/revista21-4-2009/2-Prevalencia%20de%20Depressao%20Maior.pdf

Moxoto I, Boa-Sorte N, Nunes C, Mota A, Dumas A, Dourado I, et al. Sociodemographic, epidemiological and behavioral profile of women infected with HTLV-1 in Salvador, Bahia, an endemic area for HTLV. Revista da Sociedade Brasileira de Medicina Tropical. 2007; 40(1): 37-41.

https://doi.org/10.1590/s0037-86822007000100007

Ydy RRA, Ferreira D, Souto DFJ, Fontes CJ. Prevalence of human T-cell lymphotropic virus (HTLV-1/2) infection among puerperal in Cuiabá, Mato Grosso. Revista da Sociedade Brasileira de Medicina Tropical. 2009; 42(1): 28-32.

https://doi.org/10.1590/S0037-86822009000100007

19. Figueiro-Filho EA, Senefonte FR, Lopes AH, de Morais OO, Souza Júnior VG, Maia TL, et al. Frequency of HIV-1, rubella, syphilis, toxoplasmosis, cytomegalovirus, simple herpes virus, hepatitis B, hepatitis C, Chagas’ disease and HTLV I/II infection in pregnant women of State of Mato Grosso do Sul. Revista da Sociedade Brasileira de Medicina Tropical. 2007; 40(2): 181-187.

https://doi.org/10.1590/s0037-86822007000200007

20. de Oliveira EH, Oliveira-Filho AB, Souza LA, da Silva LV, Ishak MO, Ishak R, et al. Human T-cell lymphotropic virus in patients infected with HIV-1: molecular epidemiology and risk factors for transmission in Piauí, Northeastern Brazil. Curr HIV Res. 2012; 10(6): 700-7.

https://doi.org/10.2174/1570162x11209080700

21. Marcon CEM, Campos KR, da Silva GB, Schuelter-Trevisol F, Schlindwein AD, Trevisol DJ, et al. The first survey of human T-cell lymphotropic viruses (HTLV) in HIV/AIDS patients in Santa Catarina State, Brazil. Rev Inst Med Trop São Paulo. 2019; 61: e53.

https://doi.org/10.1590/s1678-9946201961053

22. Caterino-de-Araújo A, Sacchi CT, Gonçalves MG, Campos KR, Magri MC, Alencar WK. Current prevalence and risk factors associated with human T lymphotropic virus type 1 and human T lymphotropic virus type 2 infections among HIV/AIDS patients in São Paulo, Brazil. AIDS Res Hum Retroviruses. 2015; 31(5): 543-9.

https://doi.org/10.1089/aid.2014.0287

23. Galetto LR, Lunge VR, Béria JU, Tietzmann DC, Stein AT, Simon D. Prevalence and risk factors for human T cell lymphotropic virus infection in southern brazilian HIV-positive patients. AIDS Res Hum Retroviruses. 2014; 30(9): 907-11.

https://doi.org/10.1089/aid.2013.0210

24. Brites C, Harrington Jr W, Pedroso C, Martins Netto E, Badaró R. Epidemiological characteristics of HTLV-I and II co-infection in Brazilian subjects infected by HIV-1. Braz J Infect Dis. 1997; 1(1): 42-7.

https://pubmed.ncbi.nlm.nih.gov/11107238/

25. Morimoto HK, Caterino-de-Araújo A, Morimoto AA, Reiche EM, Ueda LT, Matsuo T, et al. Seroprevalence and risk factors for human T cell lymphotropic virus type 1 and 2 infection in human immunodeficiency virus-infected patients attending AIDS referral center health units in Londrina and other communities in Paraná, Brazil. AIDS Res Hum Retroviruses. 2005; 21(4): 256-62.

https://doi.org/10.1089/aid.2005.21.256

26. Rego FFA, Mota-Miranda A, Santos ES, Castro Filho BG,

Alcantara LC Jr. Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil. AIDS Res Hum Retroviruses. 2010; 26(12): 1333-9. https://doi.org/10.1089/aid.2009.0298

27. Vallinoto ACR, Azevedo VN, Santos DEM, Caniceiro S, Mesquita FCL, Hall WW, et al. Serological evidence of HTLV-I and HTLV-II coinfections in HIV-1 positive patients in Belém, state of Pará, Brazil. Memórias do Instituto Oswaldo Cruz. 1998; 93(3): 407-409.

https://doi.org/10.1590/S0074-02761998000300026

28. Neto WK, Sanabani SS, Jamal LF, Sabino EC. Prevalence, risk factors and genetic characterization of human t-cell lymphotropic virus types 1 and 2 in patients infected with human immunodeficiency virus type 1 in the cities of Ribeirão Preto and São Paulo. Revista da Sociedade Brasileira de Medicina Tropical. 2009; 42(3): 264-270.

https://doi.org/10.1590/S0037-86822009000300006

29. Etzel A, Shibata G, Rozman M, Jorge ML, Damas CD, Segurado AA. HTLV-1 and HTLV-2 infections in HIV-infected individuals from Santos, Brazil: seroprevalence and risk factors. J Acquir Immune Defic Syndr. 2001; 26(2): 185-190. https://doi.org/10.1097/00042560-200102010-00015

30. Sodré HRS, Matos SB, Jesus ALSR, Lima FWM. Seroepidemiology of HTLV-I/II infection among population assisted by family health program in Salvador-Bahia, Brazil. Revista Brasileira de patologia Médica Laboratorial. 2010; 4(5): 369-374.

https://doi.org/10.1590/S1676-24442010000500005

31. Moreira M, Ramos A, Netto EM, Brites C. Characteristics of co-infections by HCV and HBV among Brazilian patients infected by HIV-1 and/or HTLV-1. The Brazilian Journal of infectious diseases. 2013; 17:661-666

https://doi.org/10.1016/j.bjid.2013.04.009

32. Gascon MRP, Capitão CG, Nogueira-Martins MCF, Casseb J, Oliveira ACP. Impotence and helplessness: Reflections about parentes with HAM/TSP in the HTLV context. Revista Panam Infectologia. 2011; 13(3):36-41

https://silo.tips/download/impotencia-e-desamparo-reflexoes-acerca-de-pais-com-ham-tsp-no-contexto-do-htlv

33. Lima LHM, Viana MC. Prevalence and risk factors for HIV, syphilis, hepatitis B, hepatitis C, and HTLV-I/II infection in low-income postpartum and pregnant women in Greater Metropolitan Vitória, Espírito Santo State, Brazil. Caderno de Saúde Pública. 2009; 25: 668–676.

https://doi.org/10.1590/S0102-311X2009000300021

34. Nelson PK, Mathers BM, Cowie B, Hagan H, Des Jarlais D, Horyniak D, et al. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet. 2011; 378: 571–583.

35. Machado Filho AC, Sardinha JF, Ponte RL, Costa EP, da Silva SS, Martinez-Espinosa FE. Prevalence of infection for HIV, HTLV, HBV and of syphilis and chlamydia in pregnant women in a tertiary health unit in the western Brazilian Amazon region. Rev Bras Ginecol Obstet. 2010; 32(4): 173-183

https://doi.org/10.1016/S0140-6736(11)61097-0

36. Signorino DJHP, Monteiro MCM, de Sá CAM, Sion FS, Neto HGL, Lima DP, et al. Prevalence of HIV-syphilis coinfection in a university hospital in the city of Rio de Janeiro. Revista da Sociedade Brasileira de Medicina Tropical. 2007; 40(3):282-285.

https://doi.org/10.1590/s0037-86822007000300006

Publicado

2023-01-05

Edição

Seção

Artigos Originais

Como Citar

1.
PREVALÊNCIA DA COINFECÇÃO HIV-1/HTLV-1 E RISCO COMPORTAMENTAL ENTRE PESSOAS VIVENDO COM HIV EM BELO HORIZONTE, BRASIL. Rev. Salud Pública (Córdoba) [Internet]. 5º de janeiro de 2023 [citado 22º de novembro de 2024];28(2). Disponível em: https://revistas.psi.unc.edu.ar/index.php/RSD/article/view/38078