Mucoepidermoid carcinoma of palate, palatine tonsil, and nasopharynx: a salivary gland tumor with a rare location
Keywords:
mucoepidermoid carcinoma; palate; palatine tonsil; nasopharinxAbstract
Mucoepidermoid carcinoma (MEC) it is the most common malignant tumor of the salivary gland. Regarding the minor salivary glands, it is more common in palate. An unusual case of MEC is presented located on the hard and soft palate, palatine tonsil, and right nasopharynx where histologic grade and proliferative potential as prognostic factors were analyzed. 73 years-old female patients consulted by exophytic tumor of the palate with 3 months of evolution. Incisional biopsy reported MEC of high-grade malignancy, so the surgical removal of the lesions was performed on palate, palatine tonsil and nasopharynx confirming that diagnosis. The high degree MEC is associated with aggressive behavior and reduced survival rate compared with tumors of low and intermediate malignancy. The results show its aggressiveness, high cell proliferation and infiltrative capacity, which require the early treatment and monitoring of the patient.
References
Luna MA. Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol 2006; 13: 293-307.
2. Whaley D., Gupta S, Erickson A. Mucoepidermoid carcinoma. Mayo Clin Proceed 2023; 98/9: 1427-1428. https://doi.org/10.1016/j.mayocp.2023.O7.018.
3. Ávila RE, Samar ME, Ferraris R, La Rosa F. Oncocytic mucoepidermoid carcinoma of the submandibular salivary gland: A challenging differential diagnosis of a very rare tumor. Ann Clin Case Rep 2019; 4. Article 1726.
4. Avila RE, Samar ME, Fonseca IB, Olmedo LA, Asís OG, Ferraris RV. Mucoepidermoid carcinoma of salivary glands: histological and immunohistochemical prognostic factors. Int J Morphol 2011; 29: 455-462.
5. Shafique K, Zhang PJ, Montone KT, Song S, Livolsi VA, Baloch Z. Pathologic grading of mucoepidermoid carcinomas of the salivary gland and its effect on clinicopathologic follow-up: an institutional experience. Hum Pathol 2020; 98: 89-97. doi: 10.1016/j.humpath.2020.02.001.
6. Peraza A, Gómez R, Beltrán J, Amarista FJ. Mucoepidermoid carcinoma. An update and review of the literature. J Stomatol Oral Maxillofac Surg 2020; 121(6): 713-720. doi: 10.1016/j.jormas.2020.06.003.
7. Auclair PL, Goode RK, Ellis GL. Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation
and application of grading criteria in 143 cases. Cancer 1992; 69: 2021-2030.
8. Samar Romani ME, Ávila Uliarte RE, Fonseca Acosta IB, Gomez Rosso MA, Mazzeo Strazza MA, Bachmeier Valberde E. Expresión inmunohistoquímica de Ki67 y CD34 como marcadores de proliferación y angiogénesis en el carcinoma mucoepidermoide de glándulas salivales. REFO 2023; 16: 32-38.
9. Ellis GL, Auclair PL. AFIP Atlas of tumor pathology. Series 4. Fascicle 9. Tumors of the salivary glands. Washington DC: Armed Forces Institute of Pathology (AFIP), 2008.
10. Rached L, Saleh K, Casiraghi O, Even C. Salivary gland carcinoma: Towards a more personalised approach. Cancer Treat Reviews 2024; 124:102697.
11. World Health Organization. WHO Classifications of Tumours. Head and Neck Tumours. Part A. Volume 9: WHO. 5th ed. Lyon, IARC Publicatios, 2022.
12. Shah K, Fruitwala A., Lange J, Pund M, Lahoti A. Mucoepidermoid carcinoma of the palate. A rare case report and management. J Dent Panacea 2023; 5/3: 130-133.
13. Avila Uliarte RE, Samar Romani ME, Corball de Santiago AG, Fonseca Acosta IB. Carcinoma mucoepidermoide de la base de la lengua: presentación de dos casos de localización infrecuente. Patología Rev Latinoamer 2015; 53: 207-211.
14. Chao Xu X, Chao SS, Ong YK. Endoscopic endonasal resection of recurrent nasopharyngeal mucoepidermoid carcinoma. J Craniofac Surg 2016; 27:1053-1055. doi: 10.1097/SCS.0000000000002618.
15. Ollero JM, Morón AH, Luis AM, Sánchez SM, Nazarewsky AA, López MJ, Aguerri AR. Nasopharyngeal mucoepidermoid carcinoma: A case report and review of literature. Rep Pract Oncol Radiother 2012 20; 18:117-120. doi: 10.1016/j.rpor.2012.10.002.
16. Hemalatha AL, Sharat Kumar HK, Geetanjali S, Giripunja M, Shashikumar SD. Nasopharyngeal mucoepidermoid carcinoma- A rare entity at an uncommon location. J Clin Diag Res 2014; 8: 164-165.
17. Goh GH, Lim CM, Vanacek T, Michal M, Petersson F. Spindle cell mucoepidermoid carcinoma of the palatine tonsil with CRTC1-MAML2 fusion transcript: Report of a rare case in a 17-year-old boy and a review of the literature. Int J Surg Pathol 2017; 25: 705-710. doi: 10.1177/1066896917714890.
18. Jarvis SJ, Giangrande V, Brennan PA. Mucoepidermoid carcinoma of the tonsil: a very rare presentation. Acta Otorhinolaryngol Ital 2013; 33: 286-288.
19. Teixeira LN, Martins Montalli, VA, Santana Texeira LC, Passador-Santos F, Borges Soares A, Cavalcanti de Araújo V. Mucoepidermoid carcinoma of thepalatine tonsil. Case Rep Oncol Med 2015; 2015:827560. doi:10.1155/2015/827560.
20. Sharma A, Kumar KR, Gosavi S. Mucoepidermoid carcinoma of the palatine tonsil: a rare case report. J Dent Med Sci 2019; 18: 53-56.
21. Karkuzhali P, Sahoo B. Mucoepidermoid carcinoma of the palatine tonsil: a case report and review of the literature. Int J Otorhinolaryngol Head Neck Surg 2017 3:1111-1113.
22. Carlson E., Schlieve T. Salivary gland malignancies. Oral and Maxillofac Surg Clin North Am 2019; 31, 125–144. doi: 10.1016/j.coms.2018.08.007.
23. Alsanie I, Rajab S, Cottom H, Adegun O, Agarwal R, Jay A et al. Distribution and frequency of salivary gland tumours: An international multicenter study. Head Neck Pathol 2022; 16:1043-1054. doi: 10.1007/s12105-022-01459-0.
24. Sarmento DJ, Morais ML, Costa AL, Silveira ÉJ. Minor intraoral salivary gland tumors: a clinical-pathological study. Einstein (Sao Paulo). 2016; 14:508-512. doi: 10.1590/S1679-45082016AO3749.
25. Wyszinska-Pawelec G, Gontarz M, Zapala J, Azuta M. Minor salivary gland tumours of upper aerodigestive tract: a clinicopathological study. Gastroenterol Res Pract 2012; 2012: 780453. doi: 10.1155/2012/780453.
26. Živković N, Kostić M, Cvetanović A, Jovičić Milentijević M, Spacić M, Petrović M, Trtajković M, Denčić T, Krtinić D. Differential challenges in salivary gland neoplasms. Arch Biol Sci 2021; 73: 65-72.
27. Kumar N, Narayan M, Rajkumar K, Vasanthi V. Expression of Pan-cytokeratin (AE1/AE3) in oral squamous cell carcinoma and potential malignant oral disorders. A comparative systematic review. Asian Pacific J Cancer Care 2022. doi 10.31557/apjcc.2022.7.2.357-362.
28. Souza Acevedo R, Paes de Almeida O, Kowalski LP, Pires FR. Comparative cytokeratin expression in the different cell types of salivary gland mucoepidermoid carcinoma. Head Neck Pathol 2008; 2: 257-264.
29. Robinson L, van Heerden M, Ker-Fox JG, Hunter KD, van Heerden WFP. Expression of mucins in salivary gland mucoepidermoid carcinoma. Head Neck Pathol 2021; 15: 491-502.
30. Gomez Rosso María A, Samar Romani María E, Ávila Uliarte Rodolfo E, Fonseca Acosta Ismael B, Corball de Santiago Alberto G, Ferraris Zunino Ricardo V. Expresión de la mucina asociada a membrana MUC-1/ y su relación con Ki67 en el carcinoma mucoepidermoide de glándulas salivales. RevFacOdont 2022; 32: 10-18.
31. Kaymakçı D, Sarı M, Cinel L. Adenoid cystic carcinoma of the palatine tonsil. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; 119, e215. doi: 10.1016/j.oooo.2014.07.503.
32. Kim HS, Choi KH. Acinic cell carcinoma of the palatine tonsil: A brief case report. Korean J Pathol 2010; 44:441-443.
33. Thompson LDR, Bishop JA. Update from the 5th edition of the World Health Organization Classification of Head and Neck Tumors: Nasal cavity, paranasal sinuses and skull base. Head Neck Pathol 2022; 16:1-18. doi: 10.1007/s12105-021-01406-5.
34. Buch SA, Babu GS, Castelino RL, Shruthi Rao S, Kumuda Rao K. A rare case of long-standing mucoepidermoid carcinoma of minor salivary glands of the palate. Stomatologija Baltic Dent Maxillofac J 2019; 21: 92-99.
35. De la Torre-González CD, Jaurrieta N, Sadowinski S. Sialometaplasia necrotizante en paladar duro y sus diagnósticos diferenciales An ORL Mex 2023; 68: 80-85.
36. Gutiérrez-Domingo A, Toledano-Valero P, Olmos-Juárez E. Sialometaplasia necrotizante: una entidad simuladora. Rev Esp Cirug Oral Maxilofac 2020; 42. https://dx.doi.org/10.20986/recom.2020.1118/2020
37. Thompson RDR, Wening BM. Diagnostic pathology. Head and Neck E-book. Elsevier Health Sciences 2016.
38. Carlson ER, Ord RA. Salivary gland pathology. Diagnosis and management, 3º edición. New Jersey. Wiley Black Rowell. 2022.
39. Athanazio DA, Schultz Amorim L, Werneck da Cunha I, Ramos Moreira Leite K, Alexandre Rolim da Paz A, de Paula Xavier Gomes R, Rocha Fernandes F, Tavora F, Friedrich Faraj S, Santos Cavalcanti M, Martins Bezerra S. Classification of renal cell tumors – current concepts and use of ancillary tests: recommendations of the Brazilian Society of Pathology. Surgical and Exp Pathol 2021; 4:4. https://doi.org/10.1186/s42047-020-00084-x.
40. Augustine D, Sekar B, Murali S. Clear cell variant of mucoepidermoid carcinoma -A rare case report with special staining. Indian J Dent 2013; 4:215-218.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros:
- Compartir — copiar y redistribuir el material en cualquier medio o formato
- La licenciante no puede revocar estas libertades en tanto usted siga los términos de la licencia
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) después del su publicación en la revista, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).
