Anphibian model study for evolutionary respiratory control.
Abstract
Recent perinal advances have made possible that premature newborns survive increasingtly in earlier developmental stages. This babies requires sophisticated and costly critical intensive care to address the problems associated with inrnadurity of the respiratory system. In addition respiratory instability and apnea reflecting inmaturity of the respiratory control system are majar causes of morbidity and prolonged hospitalization in this highly vulnerable group of paticnts. These concerns have contributed to the development of research in respiratoy evolutionary neurobiology. While the majority of researchers working in this fieid use rodents as an animal model, recent research using in ultra brainstem preparations from bullfrog (Rana catesbetana) have reveled the technical advantages of this model to study the basic principles underlying respiratory control and its ontogeny between vertebrates. The present article review the recent advances in the area of research with special interest on episodic breathing and the role of serotoninergic and GABAergic modulation of respiratory control during development..
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