Oral leukoplakia associated with Human Papilloma Virus; a bipolar infection in a young patient
DOI:
https://doi.org/10.31053/1853.0605.v77.n4.30733Keywords:
human papilloma virus, leukoplakia, squamous cell carcinoma of head and neckAbstract
Introduction: Human Papilloma Virus could infect human epithelia, including cervical and oral keratynocites, leading to the development of dysplastic or malignant changes. Regarding the oral mucosa, leukoplakia is the most potentially malignant disorder associated with Papilloma Virus coinfection.
Objective: the aim of this report is to present a case of a young woman with a previous history of a high-risk cervical lesion associated with Human Papillomavirus and an oral leukoplakia associated with the same viral infection using immunohistochemical techniques.
Methodology: the case was recorded and treated at the Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba. The patient was monitored and followed-up during three years, with no evidence of disease recurrence.
Conclusion: due to the increased rates of Oral Squamous Cell Carcinomas among young patients in recent years and a supposed relationship to Human Papillomavirus infection, this case reflects a challenge not only in the diagnosis, treatment and follow-up, but also the urgent need to approach these patients in a transdisciplinary perspective. Since most of these viral lesions are usually transmitted sexually, it is necessary to promote awareness in the population about prevention and protection measures against sexually transmitted infections.
Downloads
References
1. Warnakulasuriya S. Oral potentially malignant disorders: A comprehensive review on clinical aspects and management. Oral Oncol. 2020 Mar;102:104550. doi: 10.1016/j.oraloncology.2019.104550.
2. Warnakulasuriya S, Dietrich T, Bornstein MM, Casals Peidró E, Preshaw PM, Walter C, Wennström JL, Bergström J. Oral health risks of tobacco use and effects of cessation. Int Dent J. 2010 Feb;60(1):7-30.
3. Woo SB, Cashman EC, Lerman MA. Human papillomavirus-associated oral intraepithelial neoplasia. Mod Pathol. 2013 Oct;26(10):1288-97. doi: 10.1038/modpathol.2013.70.
4. Lerman MA, Woo SB. Histopathologic features of high risk human papillomavirus-associated oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jan;117(1):120. doi: 10.1016/j.oooo.2013.05.024.
5. Doorbar J. Papillomavirus life cycle organization and biomarker selection. Dis Markers. 2007;23(4):297-313. doi: 10.1155/2007/613150.
6. Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond). 2006 May;110(5):525-41. doi: 10.1042/CS20050369.
7. Ho HC, Lee MS, Hsiao SH, Hwang JH, Hung SK, Chou P, Lee CC. Squamous cell carcinoma of the oral cavity in young patients: a matched-pair analysis. Eur Arch Otorhinolaryngol. 2008 Jul;265 Suppl 1:S57-61. doi: 10.1007/s00405-007-0496-5.
8. Moine L, Gilligan G, Piemonte E, Panico R. Risk factors for oral cancer in young people in Cordoba, Argentina. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2020 Jan;129(1):e136-7. doi: 10.1016/j.oooo.2019.06.595
9. Liu X, Gao XL, Liang XH, Tang YL. The etiologic spectrum of head and neck squamous cell carcinoma in young patients. Oncotarget. 2016 Oct 4;7(40):66226-66238. doi: 10.18632/oncotarget.11265.
10. Alsabbagh A, Robins TL, Harriman A, Jackson-Boeters L, Darling MR, Khan ZA, McCord C. Surrogate markers for high-risk human papillomavirus infection in oral epithelial dysplasia: A comparison of p16, Ki-67, and ProExC. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar;129(3):246-259.e1. doi: 10.1016/j.oooo.2019.09.019.
11. Woo SB. Oral Epithelial Dysplasia and Premalignancy. Head Neck Pathol. 2019 Sep;13(3):423-439. doi: 10.1007/s12105-019-01020-6.
12. Panico R, Piemonte E, Talavera Á, Gilligan G. Human papilloma virus–associated oral epithelial dysplasia: a series of cases with clinical features. oral epithelial dysplasia: A comparison of p16, Ki-67, and ProExC. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar;129(3):e39. doi: 10.1016/j.oooo.2019.06.118.
13. Smith EM, Ritchie JM, Summersgill KF, Klussmann JP, Lee JH, Wang D, Haugen TH, Turek LP. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer. 2004 Feb 20;108(5):766-72. doi: 10.1002/ijc.11633.
14. Gillison ML, Koch WM, Shah KV. Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease? Curr Opin Oncol. 1999 May;11(3):191-9. doi: 10.1097/00001622-199905000-00010.
15. Cossellu G, Fedele L, Badaoui B, Angiero F, Farronato G, Monti E, Liverani CA, Gorni C, Botti S. Prevalence and concordance of oral and genital HPV in women positive for cervical HPV infection and in their sexual stable partners: An Italian screening study. PLoS One. 2018 Oct 18;13(10):e0205574. doi: 10.1371/journal.pone.0205574.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 Universidad Nacional de Córdoba
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The generation of derivative works is allowed as long as it is not done for commercial purposes. The original work may not be used for commercial purposes.
How to Cite
