Anexo: prevalencia de la insulinoresistencia y su asociación con dibetes tipo 2 y otros factores de riesgo cardiovascular
Keywords:
.Abstract
Wc prcsent the results of an epidemiological research underlaken in the province of Córdoba (Argentina) with the aún of studying insulin-resistance (IR) in relation to (he increased risk for diabetes and lis association witli risk factors of arterial clisease (RFAD). Overall, there were 1413 subjects between 20 and 70 years of agc, froru both sexes (Dean Funes18.885 inhabitants; sample 715; Oncativo 13880 inhabitants: sample 696).
We studied traditional arterial risk factors (hypertension, diabetes, dvsliptclemia, obesity, sedentary life. smoking). To evaluate IR we used the homeostasis model assessment (HOMA-IR). We fourid a high prevalence of IR clearly related Lo the traditional (RFAD), thus placing these populations, representatives of national ones, among the western populations at high risk for arterial disease.
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Doval HC, Tajer CD. Evidencias en Cardiología "De los ensayos clínicos a las conductas terapéuticas".Ed GEDIC Buenos Aires (R. Arg) 2000. Kannel WB, Dawber TR, Kapan KA, Ravotsky N. Stokes J. Factors of risk tu the development of coronary disease. Six years follow up experience. The Frarningham Study. Ann Inter Mcd 1961: 55: 33-50.
Conde C: Factores de riesgo no tradicionales en la Enfermedad coronaria. En : Placa ateroesclerótica de alto riesgo. Cap. 16. R Esper y 3 Vilariño. Editores Proust Science. Barcelona (España) 2002.
Madoery R. Luquez H, de Loreclo L, Roiter H y col. Estudio de los factores de riesgo en Deán Fines (Pcia Córdoba - R.A). RevArgen Mcd 2001: III (N° 3): 103-117.
No autors usted. The slxth report of the Joint Nacional Commitee on prevention, detection, evaluation and treatnient of high blood pressure. Arch Intern Mcd. 1997: 157:2413-46.
Nigro D. Vcrgotini J. La hipertensión arterial en Córdoba (RA). Rey Fed Arg Cardiol. 1999: 28: 69-75.
Verra F (coord. Comisión de Tabaquismo en el Consenso de Prevención Primaria y Secundaria de la Enfermedad Coronaria). Integrantes y Secretario (no listados). Rev Arg Cardiol. 2001-69 (sup! 1): 12-21.
S. Kevorkof GV. Epidemiología del Tabaquismo en la ciudad de Córdoba. Tesis Doctoral FCM. UNC 1999, Madoery R y Maestros de escuelas Municipales de la Ciudad de Córdoba (no listados): Tabaquismo en escuelas primarias de Córdoba (RA) FC Argentina Cap cha - No publicado. Plaza 1, Mariscal RE Ros Jellici J. El Estudio Fucnlabrada: el tabaco como factor de Riesgo cardiovascular en niños y adolescentes. Rey Esp Cardiol 1990; 43 (7): 432-437.
Paffcnbarger R. Hyde RT, Wing AL and Chcng - Cherig H. Physical activil.y al) cause mortality and longevtty of collegue alumni. N Engl 3 Mcd 1986; 314: 605-613.
Consenso de Prevnción Primaria y Secundaria de la Enfermedad Coronaria con normatizaciones y consensos. Sedentarismo, coord. Dr. Peidro - No enumerados los integrantes. Rey Argen Cardiol 2001 - Vol 69 - Supl 1.
Rey EH. Evaluación del riesgo cardiovascular. De la teoría a la práctica. Capítulos de Cardiología SAC 2003: vol VIII, cap 3: 2-17.
Braguinsky J y col. Obesidad, Patogenia. Clínica y tratamiento. El Ateneo, Buenos Aires. 1996. Kuczniarski RJ y col. Increasing prevalence of overweight arnong US adults. JAMA. 1994; 272:205-211.
Steimberg J, Daniels S. Obesity, Insulin Resistance, Diabetes, and Cardiovascular Risk in Chilciren. An American Heart Association Scicntific Staternent From the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity. and Metabolism). Circulation. 2003; 107: 1448- 1453.
Bonadonna RC, Groop L. Kraemer N, et al. Obesity and insulin resistance secular trend in humans: a dose-response study. Metabolism. 1990:39: 452-459.
Rexrode KM, Manson JE et al. Obesity and cardiovascular disease. Curr Opin Cardiol. 1996; 11: 490- 495.
Beckman JA: Creager MA, Libby P. Diabetes and athcrosclerosis epiderniology, pathophysiology and rnanagement. JAMA. 2002: 287: 2570-2581.
Hu FB: Stampfer MJ, Solornon CG et al. The impact of diabetes mellitus on mortality from all causes and coronary hcart disease in women: 20 ycars of follow up. Arch Intern Mcd. 2001; 161: 1717-1723.
Amos AF. Zimmet E Me Carty DJ.. The rising global burden of diabetes and its complications: estímates and projectionsto l.hcyear 2010. Diabetic Mcd. 1997; 14 (Suppl 5): S 1- 5 85.
Mokdad AH, Bowman BA, Ford ES. El al. The conunuing cpidemics of obesily and diabetes in the United States. JAMA. 2001: 286: 1195- 1200.
Keys A. Coronary F-leart discase in seven countries. Nutrition 1997; 13: 250-252. MRFIT Group. The multiple risk factor intervention trial. A Nacional Study of Primary Prevention of Coronary Herat disease. JAMA 1976; 235: 825-827.
Assman G. Shulte H. The Murister Hcart Study "PROCAM" Resulls of follow up al 8 years. Eur Heart J 1998: 19 Supl. A. Grupo de trabajo de la Sociedad Argentina de Cardiología: encuesta Multicéntrica de factores de riesgo coronario (EMSAC. MR) en la población general de la Argentina. Rey Arg Cardiol 1991;59: 124-136.
Koch F, Salerno de Mina MR. Los factores che riesgo coronario en la población adulta sana de San Miguel de Tucuman. Rev Arg Cardiol 1992; 60: 441-447.
Tartaglione (h) J E, La Greca R D. Sobrepeso en una población cerrada y su relación con los factores de riesgo cardiovasculares. Rey. Arg. Cardiol. 1996; 64: 481-487.
Piskors D, Locatelli H. Factores de riesgo en la ciudad de Rosario: Estudio FAROS. Rey Fed Arg Cardiol 1995: 24:499-508.
Cardiopatía Isquémica en la mujer. (2000) http://www.tuotromedico.com/. Programa Nacional de Prevención, Diagnóstico, Tratamiento y Rehabilitación de. la Cardiopatía Isquémica. Dirección Nacional de Epidemiología. http:// bvs.sld .w/revistas/res/vol 14401/ resü 140 1.pclf Eaker E, Chesebro J, Sacks E Cardiovascular Disease in Women. Circulation Pan 1. 1993; 88(4).
The Writing Group for the PEPI 'Fríal. Effects of Estrogen or Estrogen/ Progestin Regimens on Heart Disease Risk Factors in Postnienopausal Women. JAMA. 1995: 273(3): 1110-9.
Volmaro J, Martelloto R, Simondi H, Colquc R, Sued R, Pieroni M. Un cribado clínico puede pronosticar la enfermedad arterial coronaria en la mujer. Revista Española de cardiología 1999: 52 (10): 1-6. Disponible en : URL: http:// www.secardiologia.es/ (visitada el 15/05/ 2002). Kinra S. Davey Smith G, Ocaza M. etal. Is maternal transniission of coronary heart clisease risk stronger than paternal transrnission? Heart 2003: 89: 834-838.
Sesso HD, Lee Im, Gaziano 3M, et al. Maternal and paternal history of myocardial infarction and risk of cardiovascular clisease in mcn and women. Circulation 2001: 104: 393-398.
Doberty TM, Tang N, Detrano RC. Racial differcnces in the significance of coronary calciuni in asyniptomatic black and white subset with coronary risk factors. J Am Coil Cardiol 1999; 34 (3): 787-94.
Graham Im, Daly LE, Refsum HM. Plasma hoinocysleine as a risk factor for vascular disease . The European concerted actor projel. JAMA 1997; 277: 1775-1781. Stein JH, Me Bride PF. Hiperhomocisleinemia and atherosclerotic Heart disease. Ari mt Mcd 1998: 158: 1301-1306. Boushey CJ, Beresford S, Ornen OS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular diseasc: probable benefits of increasing folic acici intake. JAMA 1997: 277: 1775-1781.
Al Obeidi ME, Philippon H. Stubss PJ. Rclationship between homocysteine. factor Vila and thrombin generation in acute coronary syndromes. Circulation 2000: 101: 372-377.
Amsterdan EA. Homocysteine and athcrosclerosis up date. Prev Cardiol 1999;2:129.
Christen WG, Ayani UA, Glynn RJ, Hennekens CH. Blood levels of homocysteinc and incrcased rik of cardiovascular disease. Causal or Casual? Arch Intern Mcd 2000; 160: 422-434.
Salornaa y, Rusi y, Peckkanen J. Haeniostatic factors and prevalent coronary Heart disease. Europ. Heart 1999:15: 1293-1299.
Kullo Ji, Gau Gt, 'Fajik AJ. Novel risk factors for atheroscicrosis. Mayo clinic Proc 2000; 75: 369-380.
Rosito OBA, Toflcr GH. Hemostatic factors as tniggers of cardiovascular events. Cardiology clinics 1996; 14: 239-250.
Rader Di. lnflammatory markers of coronary risk.N Engl J Mcd 2000: 343: 1179-1182.
Mendall MA, Patel R Ballain L. Slrachani D, Northfield C. Reactive protein and its relation lo cardiovascular risk factors. A population based cross sectional studyBMJ 1996:312:1061-1065.
Ridker PM, Cushman M. Stampfer MJ, Tracy RP, l-lcnnekens CH. Plasma concentration of reactive protein and risk of cleveloping periphcral vascular disease. Circulation 1998: 97: 425-428.
Ross R. Atherocsclerosis. An inflammatory?. N Engl 3M 1999: 340: 115-126.
Rader Di. lnflamniatory niarkcrs of coronary risk. N Engl 3 Mccl 2000; 343: 1179-1182.
Saikku PM, Leínonen M. Tenkaen U. Chlamydia pneumoniae as a risk factor for coronary heart disease in the Helsinki 35 Heart Study. Ann Intern Med. 1992; 116: 273-278.
Patel P, Mendali MA, Carrington D. Association of Helicobacter Pylori and Chiamyclia pneumoniae infcctions with coronary heart disease and cardiovascular risk factors. Br Meds 1995: 311: 711-714.
Zhou YE, Lcon MB, Waclawin MA. Association between prior cytomegalovirus infeclion and the risk restenosis aftcr coronary alhcrectomy. N Engi Mcd 1996; 335: 624-630.
Ka.ski JC, Camni AS. Chlaniydia pneumoniae infcction and coronary heart disease. J Am Coli Cardiol 1999; 34: 1440-1442.
Epstein SE, Zhu J. Lack of association on infections agents with risk of future myocardial infarction and stroke. Definitive evidence disproving the infection coronary artery disease hypotesis?. Circulation 1999: 100: 1366-1368.
Yeung AC, Vekstein VI, Krantz DS et al. The efect of atheroesclerosls on the vasomotor response of coronary arteries to mental stress. N Eng] J Mcd 1991; 325: 1551-1556.
Hjcndahl P Stress and metabolic Syndrome. An intercsting but enigrnatic associaUon. Circulation 2002; 106: 2634-2636.
Carncy RM. Psycological risk factors for cardiac events. Circulation 1998: 97: 128-129.
Jannuzi JL, Stern TA, Pasterna K, De Santis R. The influence of anxiety and depression and outconie of patients with coronary artery disease. Arch Inter Mcd 2000: 160: 1913-1921.
Sivack RY, WiaterA. Alcxitimia: la dificultad para verbalizar afectos. - Teoría y clínica; (c/colab. E. Lolas). Ed Paidos - Bs As (RA) año 1997 - 10 Edición. Denollet J, Brutsaert DL. Personality, disease severity, and the risk of long terni cardiac events in patients with a decreascd ejection fraction after myocardial infarction. Circulation 1998; 97: 167-173.
Lawlocr D, Ebrahim S. Socioeconomic positon in childhood and adulthood irisulinoresistence: cross seccional survcy usirig data frorn British Women's Heart and Health Study. BMJ 2002; 325:1-5.
Otto CM, Sind BK, Kitzrnan DW et al. Association of aortic valve sclerosis with cardiovascular rnortality and morbidity in the elderly. N Engl J Mcd 1999; 341: 142-147.
Schwartz PJ, La Royere MT, Vanoli E. Autonomic nervous system and sudden cardiac death. Circulation 1992: 85: 1-77 -1-91.
Witzum JL. The oxidation hypotcsis ofathcrosclerosis. Lancet 1994: 344: 793-795.
Modam M. Haikin H. Hyperinsulinemia: a link between hypertension, obcslty and glucosc tolerance. 3 Clin lnvest 1985; 75:809-817. Reaven O. 'BantingLecture 1988". Role of insulin-resistance in Human discase. Diabetes 1988; 37: 1595-1607.
Fagan T, Deedwania PD. "The Cardiovascular dismetabolic Sindronie". ArnJ Mcd 1998; 105: 775-85.
WcndorfM, Golfine ID. Archeolo' of NIDDM. Excavation of the 'Thrifty" genotype. Diabetes 1991:34:457-462.
Garg A. Insulin resistance in the pathogenesis of Dyslipidemia. Diabetes Carc 1996; 19:387-389.
Juhan - Vague I. Increased plasma plasminogen activator inhibito - levels: a possiblc link between insulin resistance and Atherotrombosis. Diabetología 1991: 34: 457-462.
Groop LC. Insulin resistance. The fundamental trigger of type 2 diabetes. Diabetes, Obesity and Metabolism 1999; 1: SI. S7. Sheperd P. Kahn B. Glucose Transporters and insulin action. N Eng 3 Mcd 1979; 341: 248-256.
Despres Jx Px, Lamarche Rx. Hyperinsulinemia as an indepcndent risk factor for ischemic heart disease. N Eng J Mcd 1996; 334 (15): 461-469.
Fontbonne A, Eschurew E. Insulin and cardiovascular disease. "Paris Prospcctive study". Diabetes Care 1991; 14: 461-469.
Kaplan N. The dcadly quartet: upper - body obesity glucose intolerance, hypertrigliccrideniia and Hypertension. Arcli InLern mcd 1998; 149:1514-1520.
De Fronzo RA, Cooke C. The cffect of irisulin in renal handing of sodium, potassium, calciurn and phosphate tu man. J Clin invcst 1975: 55: 845-855.
Julius S. Tecumseh blood pressure Study. JAMA 1990; 264:354-358,
Palatini P Julius S. Frecuencia cardíaca y riesgo cardiovascular. Iberoamerican Journal of hypertension 1997: 1:29-43. Brook RD, Julius S. Autonomic imbalance, hypertensiori and Cardiovascular Risk. Am J Hipertension 2000; 13:112-122S.
Orillo M, Laurezi M. Hematocrit, blood pressurc and Hypertension. The Gubhio population Study. Hypertension 1992:20:319-326. Kissebach AH, Vydclingum N. Relation of body fa( distribution lo Metabolic Complications of obesity. J Clin Endocrinol Metab 1982; 54:254-260.
Shizuya Yaniashita, Tadashi N. Insulin resistance and Body fat distrihution. Diabetes care 1996; 19:287-290.
Reaven G. Metabolic sindrome. Pathofisiology and Implications for Managment of Cardiovascular discase. Circulation 2002; 106: 286-288. Mcigs JB, DAgostino R. Risk variable clustering in the Insulin resistance syndrome. The Framingham offspring Study. Diabetes 1997; 46: 1594-1600.
Maison P Byrne C. The different dimcnsions of the metabolic syndrome change together over time?. Diabetes Care 2001; 24: 1758-1763. DenKe Margo. Metabolic Syndrome. Current Atherosclerosis Report. 2002; 4: 444-447.
Tuomilenlo J, Lindstrom J. Prevention of tvpe II diabetes mellitus by Changes in Lifestyle among subjets with irupaired glucose Tolerance. N Eng J Med 2001; 344:1343-50.
Laaksorien D. Laaka H. Low leveis of icisure-lime physical activity and cardiorespiratory flness predict developmcnt of the metabolic syndrome. Diabetes Care 2002; 25: 1612-1618.
Yudkin J C. Stehouwer C D. C-Reactive Protein in healthy subjets: asociations with obesity insuliri resistance, and endothelial dysfunction. Arterioscler Tromb Vasc Biol 1999; 19: 972-978.
Fosta A, D'Agostino R. Cronic Subclinical Inflamation as part of the Insulto resistance syndrome. The Insulin Resistance Atherosclerotic Study (IRAS). Circulation 2000: 102: 42-47.
Hiendahl P. Stress and the Metabolic Sindrome. An Interesting but enigmatic association. Circulation 2002; 106: 2634-2636.
Goya W, Wincup P Influence of father's social class on cardiovascular disease in middle - aped mcn. Lancel 1996; 348: 1259-1263.
Alberti KG, Ziminet P Definition, diagnosis and classification of diabetes mellitus and jis complications. Part 1: Diagnosis and classifications of Diabetes Mellitus provisional report of a WHO consultation. Diabetes Mcd 1998; 15: 539-553.
Laaka H, Laaksonen D. The metabollc Syndrome and total and Cardiovascular Disease Mortality in Midle -aged meo. JAMA 2002; 288: 2709-2716.
Executive summary of the Third report of The National Cholesterol Education Program (NCEP) Expert Panel oil Detcction evaluation and Treatnicnt of hight blood Cholesterol in adults. JAMA 2001; 285: 2486-2497.
Park Y. W ZIiu S. The Metabolic Sindrorrie: Prevalence and associated risk factors firidings in the US population from The Third National health and Nutrition Survey. 1988-1994. Arch intern Mcd 2003; 163(4) 427-436.
Me F'arlane ST: Insuline resistance and cardiovascular disease.. Circulation 2001; 86: 713-718.
Wallace TM, Matthews DR. The assesmcnt of insulin rcsistence in man,. Diabetes Mcd 2002; 19 (7): 527-534.
Maculey KA, Williams SM, Mann JI el al.. Diagnóstico de irisulinoresistencia en la población general. Búsqueda del método más apropiado. Diabetes care 2001:24(3): 460-464.
Shinohara K, ShojiT. Emolo M. Tahara H, Koyama H, Ishimura E, Tabala N, Nishizawa Y. Insulto resistance as an inclependent predictor of cardiovascular mortality in patients with end-stage renal isease. J Am Soc Nephrol 2002; 13 (7): 1894-1900.
Hariley AJ, Williams K, Stern MFi Hafrier SM.. Homeostasis model assestment of insulin rcsistence in relation to the incidence of myocardial infarction and death Diabetes Med 2002; 19(6): 470-475.
Heablad B, Nilson F Engstrorn G, Berglund G, Janson L. Insuline resistance lo non-diabetic subjets is associated with increased incidence of myocardial infarciion and death. Diabetes Med 2002; 19(6): 470-473.
Haffner SM, Gonzalez C. A prospective analysis ofHOMAmodel. The México city Diabetes Study. Diabetes Care 1996; 19: 1139-1141. Bonora E, Formetini O, Calcoterra F et al HOMA - estimated insulin resistance is an independent predictor of cardiovascular Diseasc in Type 2 Diabetic Subjccts. Diabetes Care 2002; 25 (7): 1135-1141.
Ford ES, Giles MS, Dietz WH. Prevalence of the Metabolic Syndrome amongus adults. JAMA 2002; 287 (3): 356-359.
Schagrodsky HE, Ciruzzi M. Prevalencia de factores de riesgo de infarto agudo de miocardio. Estudio multicéiitrico. Rey. Arg Cardiol, 1992; 60 (4): 351-369.
OMS - Génova 1978: Arterial Hypertension Technical Report series N° 628. Consejo Argentino de Hipertensión arterial "E Braun Menéndez - Criterios de clasificación y tratamiento. 2a Edición Bs As 1987: 37-43. Mosa L, Mansora JE, 5utherland SE, Sanger RD. Cardiovascular Diseases in women.. Circulation 1997; 96: 2468-2482.
OMS. Informe técnico del Comité de Expertos en Diabetes. N0646. Ginebra. 1980 Europcan Atherosclerosis Society - Preventon of coronary heart disease. Nutr Metab Cardiovas Dis 1992: 2: 113-156.
Lenipiainem P, Mykkanen, Pyoralak, Laakso M, Kousisto J. Insuline resistance syndrome predicts coronary heart disease events lo the elderly non diabetic men. Circulation 1999; 86: 1123-1128.
Ahbasi F. Brown B, Samendola C, Me Laughlim T, Reaven G. Rclationship between obesity, insulin resistance and coronary heart disease risk. J Am Col] Cardiol 2002; 40 (5): 937-943.
Cnop M, Vidal ,J, Knowles NG. The concurrent acumulation of introabdominal and subcutaneous fat explain the association hetween insuline - resistence and plasma leptin concentration. Diabetes 2002:51(4): 1005-1015.
Seidell JC. Obesity in Europe: saling and epidemia lot 3 Ob 1995:9 (Suppl 3)51 54. Kanauchi M, Tsujimoto N. Hashimoto T. Validation of simples indices to asses insulin scnsitivity hased 0fl the oral glucose tolerancc test in the japanese population. Diabetes Res Clin Pract 2002: 55 (3): 229-235.
Siani A, Cappuccio FE Barba G: The relationship of wais circunsference to blood pressure: The olivetti Heart Study. AnierJ of Hypertenston 2002: 15(9): 780-786. Berrios Carrasolo X, Jadue Hund L. Factores de riesgo de enfermedad crónica.Estudio en población general de la región metropolitana. 1986- 1987- Rey Med Chile 1990; 118: 597 - 604.
Report of the commitee of principal invcstigators. Wi-lO cooperativc Trail to primary prevention of ischemic heart discase. Lancet 1980. Coniglio R., Castillo S, Dahinten E, Doubria Ml y col..Factores de riesgo para ateroesclerosis. Medicina (Bs As) 1994; 54 (2): 117-128. Camacho Hernández, Corona Muñiz 1. Factores de riesgo para cardiopatía isquémica en México. Arch lnst Cardiol Mex 1995: 65 (4): 315-22. American Diabetes Asociation - Scrccning for Diabetes. Diabetes Care 2002; 25 (Supl 1): 21-24.
Hv FB, Stampfer MJ, Haffner SM. Elevated Risk of cardiovascular disease prior lo clinical of type 2 Diabetes. Diabetes Care 2002: 25 (7): 1129-1134.
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