Utilidad del micofenolato de mofetilo en la nefritis lupica
DOI:
https://doi.org/10.31053/1853.0605.v69.n4.20885Resumo
Micofenolato de Mofetilo (MM) es un agente inmunosupresor que fue inicialmente usado para prevenir el rechazo en trasplante de órganos sólidos, y que luego se utilizó para tratar enfermedades autoinmunes sistémicas.En el Lupus Eritematoso Sistémico (LES) se utilizó inicialmente para el tratamiento de la Nefropatía Lúpica (NL) y es considerado hoy un importante agente alternativo para la NL refractaria a otros fármacos así como en el tratamiento de inducción con resultados prometedores y menor toxicidad1-3.
Los primeros estudios se limitaron a describir series con escaso número de pacientes donde MM se utilizó para tratar pacientes con enfermedad resistente al uso de Ciclofosfamida (CF) y Azatioprina (AZA) con resultados favorables.
Posteriormente varios estudios randomizados demostraron resultados satisfactorios en el tratamiento de la NL tanto en la inducción de la remisión como en el mantenimiento, comparados con el uso de CF y AZA6-9.
Los buenos resultados obtenidos en el tratamiento de la NL llevaron a que el MM comenzara a usarse para el tratamiento de otras manifestaciones de la enfermedad, tales como vasculitis, neurológicas, cutáneas, hematológicas y signos o síntomas de actividad de la enfermedad en general.
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