Efficacy of platelet-rich plasma on venous ulcers. Systematic review
DOI:
https://doi.org/10.59843/2618-3692.v25.n44.44146Keywords:
venous ulcers, platelet-rich plasma, treatment, revisionAbstract
Introduction: Venous ulcers are painful open sores that are difficult to heal. Treatment can be challenging, depending on the complexity of the wound, and may require the use of several therapies. Recently, the use of platelet-rich plasma in these patients has been suggested as a novel treatment. The objective of this work is to carry out a review on the effectiveness of platelet-rich plasma in venous ulcers.
Method: A review was carried out following the PRISMA regulations. The databases of PubMed, Cinahl, PsycINFO, SPORTDiscus, Academic Search Complete, Lilacs, IBECS, CENTRAL, SciELO, and WOS were consulted. The Cochrane tool was used to assess the risk of bias.
Results: Platelet-rich plasma is effective in venous ulcers. The total sample was 311 patients from seven clinical trials. The duration of therapy ranges from 6 to 24 weeks. All studies showed safety, tolerability and no major side effects.
Conclusions: Platelet-rich plasma is an effective and safe method to accelerate healing, reduce the area of ulcers and reduce pain in patients. Furthermore, this therapy does not increase bacteriological growth or microbial load in chronic venous ulcers.
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