Keywords
scientific evidence
psychoneuroendocrineimmunology (PNEI)
epigenetics
reductionism
How to Cite
Abstract
In April 2022 the authors published, by invitation of an international journal of molecular biology, an extensive review reporting the main scientific evidence on the relationship between psychic life and biology, drawing some general conclusions about psychology and medicine Bottaccioli et al., 2022). The present article takes up some of the key passages presented in that review.
References
AAlexander, F. (1939). Psychological aspects of medicine. Psychosomatic Medicine, 1(1), 7-18.
American Psychological Association (2013). Recognition of psychotherapy effectiveness. [Riconoscimento dell’efficacia della psicoterapia]. (Trad. It. P. Migone) Psicoterapia e Scienze Umane, 47(3), 407-422. https://doi.org/10.3280/PU2013-003001.
Bastianelli, L., Bianchi, A., Bottaccioli, F., Cardone, R., Cutrona, I.R., Palo, G., Sinibaldi, F., Stoppele, E., Tossici, G. y Vaccaro, L. (2021), Un nuovo paradigma per le scienze e le professioni psicologiche e psichiatriche. PNEI Review, 9(1). 12-69. https://doi.org/10.3280/PNEI2021-001002
Bermick, J., y Schaller, M. (2022). Epigenetic regulation of pediatric and neonatal immune responses. Pediatric research, 91(2), 297–327. https://doi.org/10.1038/s41390-021-01630-3.
Bonduriansky R. y Day T. (2020). Extended Heredity: A New Understanding of Inheritance and Evolution. [L’eredità estesa. Una nuova visione dell’ereditarietà e dell’evoluzione]. FrancoAngeli. (Trabajo original publicado en 2018). La cita deberia ser Bonduriansky, et al., 2018/2020)
Bottaccioli F. y Bottaccioli A. G. (2022). Fondamenti di psiconeuroendocrinoimmunologia. Introduzione alla scienza che studia le relazioni mente-corpo. Red.
Bottaccioli, A. G., Bologna, M., y Bottaccioli, F. (2022). Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences-A Narrative Review. International journal of molecular sciences, 23(7), 3932. https://doi.org/10.3390/ijms23073932
Bottaccioli, A. G., Bottaccioli, F., y Minelli, A. (2019). Stress and the psyche-brain-immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review. Annals of the New York Academy of Sciences, 1437(1), 31–42. https://doi.org/10.1111/nyas.13728
Bottaccioli, A. G., Bottaccioli, F., Carosella, A., Cofini, V., Muzi, P., y Bologna, M. (2020). Psychoneuroendocrinoimmunology-based meditation (PNEIMED) training reduces salivary cortisol under basal and stressful conditions in healthy university students: Results of a randomized controlled study. Explore (New York, N.Y.), 16(3), 189–198. https://doi.org/10.1016/j.explore.2019.10.006
Bottaccioli, F. (2014a). Epigenetica e Psiconeuroendocrinoimmunologia. Le due facce della rivoluzione in corso nelle scienze della vita. Saggio scientifico e filosofico. Milano: Edra
Bottaccioli, F. (2014b). Epigenetica e Psiconeuroimmunoendocrinologia: Una rivoluzione che integra psicologia e medicina. Psicoterapia e Scienze Umane, 48, 4: 597-620. https://doi.org/10.3280/PU2014-004003.
Bottaccioli, F. (2020). Filosofia per la medicina. Medicina per la filosofia. Oriente e Occidente a confronto. (Nuova edizione ampliata). Tecniche Nuove.
Bottaccioli, F. (2022). Filosofia dell’immunologia. Nuove idee per la biologia e la filosofia. Cum-Scientia, 4(7), 33-53. https://doi.org/10.57610/cs.v4i7.126
Bottaccioli, F. y Bottaccioli, A. G. (2020). Psiconeuroendocrinoimmunología y ciencia del tratamiento integrado. El Manual. Edra.
Bottaccioli, F., Carosella, A., Cardone, R., Mambelli, M., Cemin, M., D'Errico, M. M., Ponzio, E., Bottaccioli, A. G., y Minelli, A. (2014). Brief training of psychoneuroendocrinoimmunology-based meditation (PNEIMED) reduces stress symptom ratings and improves control on salivary cortisol secretion under basal and stimulated conditions. Explore (New York, N.Y.), 10(3), 170–179. https://doi.org/10.1016/j.explore.2014.02.002
Bower, J. E., Shiao, S. L., Sullivan, P., Lamkin, D. M., Atienza, R., Mercado, F., Arevalo, J., Asher, A., Ganz, P. A., y Cole, S. W. (2018). Prometastatic Molecular Profiles in Breast Tumors From Socially Isolated Women. JNCI cancer spectrum, 2(3), pky029. https://doi.org/10.1093/jncics/pky029.
Bower, J. E., y Irwin, M. R. (2016). Mind-body therapies and control of inflammatory biology: A descriptive review. Brain, behavior, and immunity, 51, 1–11. https://doi.org/10.1016/j.bbi.2015.06.012.
Buric, I., Farias, M., Jong, J., Mee, C., y Brazil, I. A. (2017). What Is the Molecular Signature of Mind-Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices. Frontiers in immunology, 8, 670. https://doi.org/10.3389/fimmu.2017.00670.
Chen, H., Li, J., Wei, D., Rostila, M., Janszky, I., Forsell, Y., Hemmingsson, T., y László, K. D. (2022). Death of a Parent and the Risk of Ischemic Heart Disease and Stroke in Denmark and Sweden. JAMA network open, 5(6), e2218178. https://doi.org/10.1001/jamanetworkopen.2022.18178.
Chen, M., y Lacey, R. E. (2018). Adverse childhood experiences and adult inflammation: Findings from the 1958 British birth cohort. Brain, behavior, and immunity, 69, 582–590. https://doi.org/10.1016/j.bbi.2018.02.007.
Chen, W. G., Schloesser, D., Arensdorf, A. M., Simmons, J. M., Cui, C., Valentino, R., Gnadt, J. W., Nielsen, L., Hillaire-Clarke, C. S., Spruance, V., Horowitz, T. S., Vallejo, Y. F., y Langevin, H. M. (2021). The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self. Trends in neurosciences, 44(1), 3–16. https://doi.org/10.1016/j.tins.2020.10.007.
Cole, S. W., Capitanio, J. P., Chun, K., Arevalo, J. M., Ma, J., y Cacioppo, J. T. (2015). Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation. Proceedings of the National Academy of Sciences of the United States of America, 112(49), 15142–15147. https://doi.org/10.1073/pnas.1514249112.
Davies, C., Appiah-Kusi, E., Wilson, R., Blest-Hopley, G., Bossong, M. G., Valmaggia, L., Brammer, M., Perez, J., Allen, P., Murray, R. M., McGuire, P., y Bhattacharyya, S. (2022). Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report. European archives of psychiatry and clinical neuroscience, 272(3), 461–475. https://doi.org/10.1007/s00406-021-01318-z.
de Oliveira, K. C., Camilo, C., Gastaldi, V. D., Sant'Anna Feltrin, A., Lisboa, B. C. G., de Jesus Rodrigues de Paula, V., Moretto, A. C., Lafer, B., Hoexter, M. Q., Miguel, E. C., Maschietto, M., Biobank for Aging Studies Group, y Brentani, H. (2021). Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC genomic data, 22(1), 45. https://doi.org/10.1186/s12863-021-00993-0.
Di Francesco, M., Marraffa, M. y Tomasetta, A. (2017). Filosofia della mente. Corpo, coscienza, pensiero. Carocci
Engel G.L. (2006). The need for a new medical model: A challenge for biomedicine. [La necessità di un nuovo modello di medicina: una sfida per la biomedicina]. (Trad. It.). Abilitazione e Riabilitazione, 15(1), 13-32).
Feng, F., Tuchman, S., Denninger, J. W., Fricchione, G. L., y Yeung, A. (2020). Qigong for the Prevention, Treatment, and Rehabilitation of COVID-19 Infection in Older Adults. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry, 28(8), 812–819. https://doi.org/10.1016/j.jagp.2020.05.012
Fioranelli, M., Bottaccioli, A. G., Bottaccioli, F., Bianchi, M., Rovesti, M., y Roccia, M. G. (2018). Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based. Frontiers in immunology, 9, 2031. https://doi.org/10.3389/fimmu.2018.02031.
Gauvrit, T., Benderradji, H., Buée, L., Blum, D., y Vieau, D. (2022). Early-Life Environment Influence on Late-Onset Alzheimer's Disease. Frontiers in cell and developmental biology, 10, 834661. https://doi.org/10.3389/fcell.2022.834661.
Gorgia (V sec. a.C. [1958]). Frammenti. Boringhieri.
Jablonka, E. y Lamb, M. (2020). Inheritance Systems and the Extended Evolutionary Synthesis. Cambridge University Press
Janet, P. (1923). La médecine psychologique. Paris: L’Harmattan, 2005 (trad. it.: La medicina psicologica. Roma: Il pensiero scientifico, 1994)
Janet, P. (1994). La médecine psychologique. [La medicina psicologica]. (Trad. It. F. Ortu) Il pensiero scientifico.
Karl, M., Huth, V., Schälicke, S., Müller-Stark, C., Weise, V., Mack, J. T., Kirschbaum, C., Weidner, K., Garthus-Niegel, S., y Steudte-Schmiedgen, S. (2023). The association between maternal symptoms of depression and hair glucocorticoids in infants across the perinatal period. Psychoneuroendocrinology, 147, 105952. https://doi.org/10.1016/j.psyneuen.2022.105952.
Kleeman, E. A., Gubert, C., y Hannan, A. J. (2022). Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility. Trends in genetics : TIG, 38(7), 662–675. https://doi.org/10.1016/j.tig.2022.03.006
Koenen, K. C. (22 de julio de 2020). Pregnant during a pandemic? Mental health of pregnant and postpartum women during COVID-19. Psychology Today. www.psychologytoday.com/us/blog/mental-health-around-the-world/202007/pregnant-during-pandemic?eml .
Lam, J. A., Murray, E. R., Yu, K. E., Ramsey, M., Nguyen, T. T., Mishra, J., Martis, B., Thomas, M. L., y Lee, E. E. (2021). Neurobiology of loneliness: a systematic review. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 46(11), 1873–1887. https://doi.org/10.1038/s41386-021-01058-7.
Lazzari, D. (2019). La psiche tra salute e malattia. Evidenze ed epidemiologia. Edra.
Lebel, C., MacKinnon, A., Bagshawe, M., Tomfohr-Madsen, L., y Giesbrecht, G. (2020). Elevated depression and anxiety symptoms among pregnant individuals during the COVID-19 pandemic. Journal of affective disorders, 277, 5–13. https://doi.org/10.1016/j.jad.2020.07.126 Erratum in: ournal of affective disorders, 279, 377–379. https://doi.org/10.1016/j.jad.2020.10.012
Lê-Scherban, F., Wang, X., Boyle-Steed, K. H., y Pachter, L. M. (2018). Intergenerational Associations of Parent Adverse Childhood Experiences and Child Health Outcomes. Pediatrics, 141(6), e20174274. https://doi.org/10.1542/peds.2017-4274.
Lopresti, A. L. (2017). Cognitive behaviour therapy and inflammation: A systematic review of its relationship and the potential implications for the treatment of depression. The Australian and New Zealand journal of psychiatry, 51(6), 565–582. https://doi.org/10.1177/0004867417701996.
Lu, Y. C., Andescavage, N., Wu, Y., Kapse, K., Andersen, N. R., Quistorff, J., Saeed, H., Lopez, C., Henderson, D., Barnett, S. D., Vezina, G., Wessel, D., du Plessis, A., y Limperopoulos, C. (2022). Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain. Communications medicine, 2, 47. https://doi.org/10.1038/s43856-022-00111-w.
Lutgendorf, S. K., Penedo, F., Goodheart, M. J., Dahmoush, L., Arevalo, J. M. G., Thaker, P. H., Slavich, G. M., Sood, A. K., y Cole, S. W. (2020). Epithelial-mesenchymal transition polarization in ovarian carcinomas from patients with high social isolation. Cancer, 126(19), 4407–4413. https://doi.org/10.1002/cncr.33060.
McEwen, B. S. (1998). Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33–44. https://doi.org/10.1111/j.1749-6632.1998.tb09546.x.
McEwen, B. S., y Akil, H. (2020). Revisiting the Stress Concept: Implications for Affective Disorders. The Journal of neuroscience: the official journal of the Society for Neuroscience, 40(1), 12–21. https://doi.org/10.1523/JNEUROSCI.0733-19.2019.
Miranda Furtado, C. L., Dos Santos Luciano, M. C., Silva Santos, R. D., Furtado, G. P., Moraes, M. O., y Pessoa, C. (2019). Epidrugs: targeting epigenetic marks in cancer treatment. Epigenetics, 14(12), 1164–1176. https://doi.org/10.1080/15592294.2019.1640546
Morrens, M., Overloop, C., Coppens, V., Loots, E., Van Den Noortgate, M., Vandenameele, S., Leboyer, M., y De Picker, L. (2022). The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis. Molecular psychiatry, 27(8), 3237–3246. https://doi.org/10.1038/s41380-022-01582-y.
Morris, M. C., Abelson, J. L., Mielock, A. S., y Rao, U. (2017). Psychobiology of cumulative trauma: hair cortisol as a risk marker for stress exposure in women. Stress (Amsterdam, Netherlands), 20(4), 350–354. https://doi.org/10.1080/10253890.2017.1340450
Nannini, S. (2021). L’anima e il corpo. Un’introduzione storica alla filosofia della mente. Laterza.
Nemirovsky, A., Ilan, K., Lerner, L., Cohen-Lavi, L., Schwartz, D., Goren, G., Sergienko, R., Greenberg, D., Slonim-Nevo, V., Sarid, O., Friger, M., Regev, S., Odes, S., Hertz, T., Monsonego, A., y Israeli IBD Research Nucleus (IIRN) (2021). Brain-immune axis regulation is responsive to cognitive behavioral therapy and mindfulness intervention: Observations from a randomized controlled trial in patients with Crohn's disease. Brain, behavior, y immunity - health, 19, 100407. https://doi.org/10.1016/j.bbih.2021.100407
Nur, S. M., Rath, S., Ahmad, V., Ahmad, A., Ateeq, B., y Khan, M. I. (2021). Nutritive vitamins as epidrugs. Critical reviews in food science and nutrition, 61(1), 1–13. https://doi.org/10.1080/10408398.2020.1712674.
Palma-Gudiel, H., Córdova-Palomera, A., Eixarch, E., Deuschle, M., y Fañanás, L. (2015). Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis. Epigenetics, 10(10), 893–902. https://doi.org/10.1080/15592294.2015.1088630.
Pariante, C. M. (2017). Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation. European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology, 27(6), 554–559. https://doi.org/10.1016/j.euroneuro.2017.04.001.
Platone (IV sec. a.C. [2001]). Tutti gli scritti. A cura di G. Reale. Bompiani
Pourriyahi, H., Yazdanpanah, N., Saghazadeh, A., y Rezaei, N. (2021). Loneliness: An Immunometabolic Syndrome. International journal of environmental research and public health, 18(22), 12162. https://doi.org/10.3390/ijerph182212162.
Prestwood, T. R., Asgariroozbehani, R., Wu, S., Agarwal, S. M., Logan, R. W., Ballon, J. S., Hahn, M. K., y Freyberg, Z. (2021). Roles of inflammation in intrinsic pathophysiology and antipsychotic drug-induced metabolic disturbances of schizophrenia. Behavioural brain research, 402, 113101. https://doi.org/10.1016/j.bbr.2020.113101
Remes, O., Mendes, J. F., y Templeton, P. (2021). Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature. Brain sciences, 11(12), 1633. https://doi.org/10.3390/brainsci11121633.
Rodriguez, N., Martinez-Pinteño, A., Blázquez, A., Ortiz, A. E., Moreno, E., Gassó, P., Lafuente, A., Lazaro, L., y Mas, S. (2021). Integrative DNA Methylation and Gene Expression Analysis of Cognitive Behavioral Therapy Response in Children and Adolescents with Obsessive-Compulsive Disorder; a Pilot Study. Pharmacogenomics and personalized medicine, 14, 757–766. https://doi.org/10.2147/PGPM.S313015.
Shields, G. S., Spahr, C. M., y Slavich, G. M. (2020). Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials. JAMA psychiatry, 77(10), 1031–1043. https://doi.org/10.1001/jamapsychiatry.2020.0431.
Sun, J., Patel, F., Rose-Jacobs, R., Frank, D. A., Black, M. M., y Chilton, M. (2017). Mothers' Adverse Childhood Experiences and Their Young Children's Development. American journal of preventive medicine, 53(6), 882–891. https://doi.org/10.1016/j.amepre.2017.07.015.
Szyf, M. (2021). Perinatal stress and epigenetics. Handbook of clinical neurology, 180, 125–148. https://doi.org/10.1016/B978-0-12-820107-7.00008-2
Tollefsbol, T. (Ed.) (2021), Medical Epigenetics. (2° ed.) Academic Press, Elsevier.
Uddin, J., Alharbi, N., Uddin, H., Hossain, M. B., Hatipoğlu, S. S., Long, D. L., y Carson, A. P. (2020). Parenting stress and family resilience affect the association of adverse childhood experiences with children's mental health and attention-deficit/hyperactivity disorder. Journal of affective disorders, 272, 104–109. https://doi.org/10.1016/j.jad.2020.03.132.
Vaiserman, A. M., y Koliada, A. K. (2017). Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?. Human genomics, 11(1), 34. https://doi.org/10.1186/s40246-017-0129-z.
van der Wal, J. M., van Borkulo, C. D., Deserno, M. K., Breedvelt, J. J. F., Lees, M., Lokman, J. C., Borsboom, D., Denys, D., van Holst, R. J., Smidt, M. P., Stronks, K., Lucassen, P. J., van Weert, J. C. M., Sloot, P. M. A., Bockting, C. L., y Wiers, R. W. (2021). Advancing urban mental health research: from complexity science to actionable targets for intervention. The lancet. Psychiatry, 8(11), 991–1000. https://doi.org/10.1016/S2215-0366(21)00047-X.
Vancampfort, D., Stubbs, B., Van Damme, T., Smith, L., Hallgren, M., Schuch, F., Deenik, J., Rosenbaum, S., Ashdown-Franks, G., Mugisha, J., y Firth, J. (2021). The efficacy of meditation-based mind-body interventions for mental disorders: A meta-review of 17 meta-analyses of randomized controlled trials. Journal of psychiatric research, 134, 181–191. https://doi.org/10.1016/j.jpsychires.2020.12.048.
Vineis, P., Avendano-Pabon, M., Barros, H., Bartley, M., Carmeli, C., Carra, L., Chadeau-Hyam, M., Costa, G., Delpierre, C., D'Errico, A., Fraga, S., Giles, G., Goldberg, M., Kelly-Irving, M., Kivimaki, M., Lepage, B., Lang, T., Layte, R., MacGuire, F., Mackenbach, J. P., … Zins, M. (2020). Special Report: The Biology of Inequalities in Health: The Lifepath Consortium. Frontiers in public health, 8, 118. https://doi.org/10.3389/fpubh.2020.00118
Vinkers, C. H., Geuze, E., van Rooij, S. J. H., Kennis, M., Schür, R. R., Nispeling, D. M., Smith, A. K., Nievergelt, C. M., Uddin, M., Rutten, B. P. F., Vermetten, E., y Boks, M. P. (2021). Successful treatment of post-traumatic stress disorder reverses DNA methylation marks. Molecular psychiatry, 26(4), 1264–1271. https://doi.org/10.1038/s41380-019-0549-3.
Watkins, A. J., Rubini, E., Hosier, E. D., y Morgan, H. L. (2020). Paternal programming of offspring health. Early human development, 150, 105185. https://doi.org/10.1016/j.earlhumdev.2020.105185.
Weaver, I. C., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., y Meaney, M. J. (2004). Epigenetic programming by maternal behavior. Nature neuroscience, 7(8), 847–854. https://doi.org/10.1038/nn1276.
Yehuda, R., Daskalakis, N. P., Desarnaud, F., Makotkine, I., Lehrner, A. L., Koch, E., Flory, J. D., Buxbaum, J. D., Meaney, M. J., y Bierer, L. M. (2013). Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD. Frontiers in psychiatry, 4, 118. https://doi.org/10.3389/fpsyt.2013.00118.
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