La asociación prenatal entre un taco quimiosensorial (Cineole) y los efectos postabsortivos del etanol modula la respuesta posterior del operador a la leche con sabor a Cineole en ratas de 1 día de edad
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Resumen
Los fetos de rata a término detectan, y asocian entre sí, las propiedades sensoriales y farmacológicas del etanol. En el presente estudio se evaluaron cambios en un aprendizaje operante, en función de las experiencias fetales con etanol. Los tratamientos prenatales fueron: Grupo "Apareado", las hembras fueron administradas con cineol y 15-min después con etanol (2.0 g/kg); Grupo "Larga-Huella", se administró cineol y 6 horas mas tarde, etanol y Grupo "Agua", las hembras recibieron dos administraciones de agua separadas por 15 minutos. Las crías fueron entrenadas en una tarea operante. Se emplearon dos condiciones de aprendizaje (apareado y acoplado). Los sujetos "Apareados" fueron entrenados bajo un esquema de reforzamiento continuo. Los sujetos "Acoplados" recibieron el reforzador de manera independiente de su conducta. Los reforzadores fueron leche o leche saborizada con cineol. Los resultados sugieren que las memorias prenatales relacionadas al alcohol pueden modular las respuestas operantes cuando las crías son re-expuestas a claves predictoras de los efectos tóxicos etílicos. Near-term rat fetuses detect and associate ethanol's sensory and postabsortive properties. We aimed to evaluate changes upon operant conditioning in neonates, as a function of prenatal ethanol-mediated associative experiences. Prenatal treatments were: Paired group, dams administered (i.g.) with cineole and 15-min later with EtOH (2.0 g/kg); Long-delay group, dams received cineole 6 hours before ethanol intoxication; Water group, dams received two administrations of water separated by 15 min. On PD1 neonates were trained in an operant task. Two different learning conditions were used. Paired pups were trained under a FR=1 reinforcement schedule. Yoked pups received the reinforcer but, unrelated to their own behavior. Milk or Cineole-flavored milk were the reinforce solutions. Present results support the idea that ethanol-related prenatal memories modulate operant responsiveness when pups are re-exposed to cues that predict toxic consequences of the drug.
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Referencias
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