Premios nobel 2011: Células dentríticas, receptores toll y sus aportes a la medicina básica y translacional

Jorge Geffner; Gabriel A. Rabinovich

doi:10.31053/1853.0605.v68.n4.21443

Authors

Jorge Geffner Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina. Buenos Aires.
Gabriel A. Rabinovich Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME). CONICET, Buenos Aires. Laboratorio de Glicómica Funcional. Departamento de Química Biológica. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires.

DOI:

https://doi.org/10.31053/1853.0605.v68.n4.21443

Abstract

On October 3 of this year the Nobel Assembly of the Karolinska Institute jointly awarded the 2011 Nobel Prize in Medicine to Bruce A. Beutler and Jules A. Hoffman in recognition of their discoveries about the activation of innate immunity. Beutler and Jules A. Hoffman in recognition of their discoveries about the activation of innate immunity, and Ralph M. Steinman for his discovery of dendritic cells and their role in adaptive immunity.

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References

Anderson KV, Jurgens G, Nusslein-Volhard C. Establish¬ment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 1985; 42: 779-89.

Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoff¬mann JA.. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973-83.

Poltorak A, He X, Smirnova, Liu MY, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: muta¬tions in Tlr4 gene.

Science 1998; 282: 2085-8.

Barton GM, Kagan JC. A cell biological view of Toll-like receptor function regulation through compartmentaliza¬tion. Nat Rev Immunol 2009; 9: 535-42.

Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140: 805-20.

Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973; 137: 1142-62.

Steinman RM. Linking innate to adaptive immunity through dendritic cells. Novartis Found Symp 2006;279: 101-9.

Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21: 685-711.

Ilarregui JM, Croci DO, Bianco G, Toscano M, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven mmunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009; 10: 981-991.

Ilarregui JM, Croci DO, Toscano MA, Bianco GA, Salatino M, Rabinovich GA. Integrating the universe of regulatory cells in cancer: a major hurdle for successful immuno therapy. Medicina (B Aires) 2007; 67: 25-31.

Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007; 449: 419-26.

Steinman RM. Decisions About Dendritic Cells: Past, Present, and Future. Annu Rev Immunol. 2011 Oct 13. [Epub ahead of print]