Premios nobel 2011: Células dentríticas, receptores toll y sus aportes a la medicina básica y translacional
DOI:
https://doi.org/10.31053/1853.0605.v68.n4.21443Resumo
El 3 de octubre del corriente año la Asamblea Nobel del Instituto Karolinska otorgó el Premio Nobel de Medicina 2011 en forma conjunta a Bruce A. Beutler y Jules A. Hoffman en reconocimiento a sus descubrimientos acerca de la activación de la inmunidad innata, y a Ralph M. Steinman por su descubrimiento de las células dendríticas y su rol en la inmunidad adaptativa.Downloads
Referências
Anderson KV, Jurgens G, Nusslein-Volhard C. Establish¬ment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 1985; 42: 779-89.
Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoff¬mann JA.. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973-83.
Poltorak A, He X, Smirnova, Liu MY, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: muta¬tions in Tlr4 gene.
Science 1998; 282: 2085-8.
Barton GM, Kagan JC. A cell biological view of Toll-like receptor function regulation through compartmentaliza¬tion. Nat Rev Immunol 2009; 9: 535-42.
Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140: 805-20.
Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973; 137: 1142-62.
Steinman RM. Linking innate to adaptive immunity through dendritic cells. Novartis Found Symp 2006;279: 101-9.
Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21: 685-711.
Ilarregui JM, Croci DO, Bianco G, Toscano M, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven mmunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009; 10: 981-991.
Ilarregui JM, Croci DO, Toscano MA, Bianco GA, Salatino M, Rabinovich GA. Integrating the universe of regulatory cells in cancer: a major hurdle for successful immuno therapy. Medicina (B Aires) 2007; 67: 25-31.
Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007; 449: 419-26.
Steinman RM. Decisions About Dendritic Cells: Past, Present, and Future. Annu Rev Immunol. 2011 Oct 13. [Epub ahead of print]
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2018 Universidad Nacional de Córdoba
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.
A geração de trabalhos derivados é permitida, desde que não seja feita para fins comerciais. O trabalho original não pode ser usado para fins comerciais.
Como Citar
