Tratamiento de micobacteriosis no tuberculosas (MNT) con quinolonas

Authors

  • Gregorio Kevorkoff Universidad Nacional de Córdoba. Facultad de Ciencias Médicas
  • Zulma Micheli Universidad Nacional de Córdoba. Facultad de Ciencias Médicas
  • Dante Nigro Universidad Nacional de Córdoba. Facultad de Ciencias Médicas

DOI:

https://doi.org/10.31053/1853.0605.v51.n2.43646

Keywords:

non-tuberculous mycobacteriosis, pulmonary lesions, treatment, quinolones

Abstract

Two cases of Non-tuberculous Mycobacterium fiom the MAl group and another by Mycobacterium Fortuitum are presented. None ofthem with extrapulmonary manifestations. They were treated with a scheme of four drugs among which the Quinolone was included. The patients were adults with pulmonary processes clinically and racliologically similar to pulmonary Tuberculosis (TBC); non-tuberculous mycobacteria were isolated from the sputurn. It has been shown "in vitro" that the non-
tuberculous mycobacteria are sensitive to the Fluorquinolones. Thus, Ciprofloxacine or Ofloxacine were used, taking into consideration the initial polirresistence to the habitual tuberculostatics. Consequently, these patients were treated with schemes which included these new Quinolones,getting good clinical responsiveness and negativization of the sputum in all the cases.

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Author Biographies

  • Gregorio Kevorkoff, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas

    Cátedra de Medicina U. U.N.C. Unidad Hospitalaria N° 5 Hosp. Tránsito Cáceres de Allende.

  • Zulma Micheli, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas

    Cátedra de Medicina U. U.N.C. Unidad Hospitalaria N° 5 Hosp. Tránsito Cáceres de Allende.

  • Dante Nigro, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas

    Cátedra de Medicina U. U.N.C. Unidad Hospitalaria N° 5 Hosp. Tránsito Cáceres de Allende.

References

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Fouret Yx: Newly documented antimi- crobial activity of quinolones. Eur Clin Microbio] Infect Dis10:249-254, 1991.

Marticorena B: Micobacteriosis no tuberculosas. Rey Cien Mcd Córdoba 45:28-32, 1987.

Neu 11 C: Sinergy and antagonism of combinations with quinolones. Eur Clin Microbiol lnfect Dis 10:255-261, 1991.

Scheld W: Evaluations of quinolones in experimental models of infections. Eur Clin Microbio] Infect Dis 10:279-290,1991.

Van Caekcnberge D: Comparative in vitro activities often fluorquinolones and fusidic acid against mycobacteriuin. J Antimicrob

Chemotherapy 26(3):381-386, 1990.

Walker R C: The fluorquinolones. Mayo Clinic Proc 66:1249-1259, 1991.

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Published

2024-02-21

Issue

Section

Original Papers

How to Cite

1.
Kevorkoff G, Micheli Z, Nigro D. Tratamiento de micobacteriosis no tuberculosas (MNT) con quinolonas . Rev Fac Cien Med Univ Nac Cordoba [Internet]. 2024 Feb. 21 [cited 2024 Nov. 22];51(2):9-14. Available from: https://revistas.psi.unc.edu.ar/index.php/med/article/view/43646

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