Keywords
psychiatry
immunology
neurology
endocrinology
bioactive lipids
resolution
homeostasis
How to Cite
Abstract
There is substantial evidence to suggest that several psychiatric conditions (including stress and depression), immunological disorders, neurological conditions, and endocrine abnormalities are low grade systemic inflammatory diseases in which pro-inflammatory mediators are substantially increased while anti-inflammatory molecules are deficient. This imbalance in the molecules involved in inflammation and immune response regulation results in the balance being shifted more towards pro-inflammatory events that can lead to the initiation, progression and continuation of the disease process(es). In such an event, methods designed to enhance the concentrations of anti-inflammatory molecules and suppressing inappropriate production and action of pro-inflammatory mediators may form a novel approach to many diseases. Cytokines, bioactive lipids and corresponding enzyme systems and their specific precursors and associated molecules seem to be at the centre of this imbalance between the pro- and anti-inflammatory events. Based on the current evidence, it is suggested that administration of appropriate amounts of bioactive lipids arachidonic, eicosapentaenoic and docosahexaenoic acids and anti-inflammatory cytokines IL-4 and IL-10 and anti-oxidants glutathione, vitamins C, B1, B6, B12 and other co-factors needed to restore the balance between pro- and anti-inflammatory events and restore homeostasis may form a new approach in the prevention and management of various diseases/disorders.
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