Uso de aspirina 100 mg / dia para prevenção da pré-eclâmpsia, em gestações de alto risco, em uma coorte da Argentina
DOI:
https://doi.org/10.31053/1853.0605.v79.n1.32783Palavras-chave:
Pré-eclâmpsia, eclampsia, Hipertensão, gravidez, aspirinaResumo
Metas
O objetivo deste estudo foi analisar a utilidade da dose de 100 mg de aspirina como medida preventiva para pré-eclâmpsia em gestantes de alto risco.
Métodos
Realizou-se estudo de coorte retrospectivo de gestantes de alto risco em acompanhamento com protocolo de pressão arterial e avaliou-se o uso de aspirina 100 mg versus não uso na incidência de PREEC. As estimativas de risco foram feitas entre os dois grupos sem e com ajuste das variáveis com modelos de regressão logística binária.
Resultados
Foram avaliadas 633 gestantes de alto risco com média de 30 ± 7 anos e 25 ± 8 semanas de gestação, sendo que 281 (44,3%) mulheres receberam aspirina.
A prevalência total do PREEC em nossa amostra foi de 151 gestantes (23,8%).
Mulheres grávidas que estavam tomando aspirina desenvolveram menos eventos PREEC (19,2% vs 27,5%, p = 0,019); com OR não ajustado 0,62 (IC 95% 0,43-0,91 p = 0,017). Esse risco é semelhante quando ajustado para idade, história de pré-eclâmpsia, diabetes mellitus e hipertensão arterial crônica. (OR ajustado 0,63 IC 95% 0,43-0,92 p = 0,017).
Conclusões
O uso de Aspirina 100 mg por dia antes da 20ª semana de gestação em gestantes de alto risco diminuiu o risco de desenvolver PREEC, independentemente da idade e dos fatores de risco.
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Referências
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